New Probiotic Formulation Shows promise in Mitigating Antibiotic-Associated Diarrhea in Children
Breaking: A novel multi-strain probiotic, SymbioLact Multi Kids, is demonstrating potential as an adjunctive therapy to reduce the incidence of antibiotic-associated diarrhea (AAD) in children. Preliminary research suggests the formulation, containing spore-forming Bacillus subtilis HU58, can definitely help restore gut balance disrupted by antibiotic use, a common and distressing side effect for young patients.
Antibiotic use,while often necessary,substantially impacts the gut microbiome,frequently leading to diarrhea. This disruption can prolong illness, necessitate further medical intervention, and negatively affect a child’s quality of life. A randomized, double-blind, placebo-controlled trial by Sorensen et al.(2025) indicated positive effects of Bacillus subtilis HU58 in children experiencing AAD. This new formulation builds on existing clinical guidelines recommending probiotic use for prevention, as outlined by Szajewska et al. in JPGN (2016), and offers a potentially more targeted approach.
SymbioLact Multi Kids is designed to support gut health during and after antibiotic treatment. The formulation aims to minimize the disruption to the gut flora, potentially reducing the severity and duration of diarrhea. Research also suggests potential benefits beyond AAD; studies have shown multi-strain probiotics can offer relief from symptoms associated with Irritable Bowel Syndrome (IBS) and bloating in adults (jafari et al., 2014), and even minimize IBS symptoms as demonstrated in a 2011 clinical case study by Nagala et al.
Furthermore, probiotics are being investigated for their role in preventing Clostridium difficile-associated diarrhea, a more serious complication, notably in adults and children (Goldenberg et al., 2017). The growing understanding of “leaky gut” and the importance of gut barrier function (Aleman et al., 2023) further underscores the potential of targeted probiotic therapies like SymbioLact Multi Kids to support overall digestive health.
Further information can be found here.
Sources:
1 Sorensen K et al.Effects of spore-forming probiotic Bacillus subtilis HU58™ in children with antibiotic-associated diarrhoea: a randomised, double-blind, placebo-controlled trial. Beneficial Microbes 2025; 1-10.
2 Szajewska H et al. Probiotics for the prevention of antibiotic-associated Diarrhea in Children. Clinical Guideline. JPGN 2016;62: 495-506.
3 Jafari E et al. Therapeutic effects, tolerability and safety of a multi-strain probiotic in Iranian adults with irritable bowel syndrome and bloating. Arch Iran Med 2014;17:466.
4 Nagala et al.2011. Clinical Case Study-Multispecies Probiotic Supplement Minimizes Symptoms of Irritable Bowel Syndrome. US Gastroenterology & Hepatology Review 2011; 7:1.(no link available)
5 Goldenberg JZ et al. Probiotics for the prevention of Clostridium difficile– associated diarrhea in adults and children (Review). Cochrane Database Syst Rev 2017;19:CD006095.
6 Aleman RS et al. Leaky Gut and the Ingredients That help Treat It: A review. Molecules 2023;28:619.
