antidepressants Show Benefit Against Depression & Anxiety Within Two Weeks, Study Finds
LONDON – New research indicates selective serotonin reuptake inhibitors (SSRIs) may begin alleviating core symptoms of depression and anxiety considerably sooner than previously believed - within just two weeks of starting treatment. A network analysis of existing randomized study data revealed this positive effect, despite initial somatic side effects often masking betterment during that period. The findings are slated for publication in Nature mental Health (2025; DOI: https://doi.org/10.1038/s44220-025-00528-x).
While ssris reach serotonin receptors in the brain within hours of administration, demonstrable effects have historically taken several weeks to emerge in clinical trials, and the difference between medication and placebo groups has frequently enough been modest. This discrepancy has long been noted given the widespread use and perceived efficacy of SSRIs among both clinicians and patients. The new analysis suggests the benefit is present earlier, but obscured by initial side effects.
