USC Favored to Win Against Illinois, But a Close Game is Projected
As of September 23, 2025, oddsmakers anticipate a victory for the University of Southern California (USC) Trojans when they face the Illinois Fighting Illini, though the contest is expected to be tightly contested. The game presents an opportunity for USC to maintain it’s undefeated season, while Illinois seeks a notable upset.
The projected outcome, based on point spreads and totals, indicates a final score of 34-26 in favor of USC. This suggests a narrow margin of victory for the Trojans, despite being favored. Game odds are dynamic and subject to change.
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