For those who haven’t experienced The Tatami galaxy, a viewing is highly recommended. Even if you’ve seen it before, revisiting it with a renewed thankfulness for its artistic direction is encouraged. While sharing stylistic similarities with Ping Pong The Animation and The Count of Monte Cristo, The Tatami Galaxy distinguishes itself by consistently pushing the boundaries of its animation.
Produced by Science SARU, each segment of the series offers a distinct visual experience, with subsequent scenes often surpassing the impact of those preceding them. The animation masterfully merges conventional anime aesthetics with a pop art sensibility and unconventional character designs, resulting in a truly singular anime.
Honorable Mention: Dandadan

While Dandadan may not be entirely unique in its visual presentation during its more subdued moments, its inclusion is warranted due to its dynamic shifts in artistic style during its high-octane action sequences.
The distinctiveness of each confrontation in Dandadan is significantly influenced by its varied artistic approaches. The visual portrayal of characters like the Flatwoods Monster, the Earthbound Spirit Crab, and Nessie contributes to their unique tones and atmospheres through their differing art styles.
What are your thoughts on this list? Are there other anime series that you believe feature notably distinctive art styles? Share your recommendations in the comments section.