why, for whom and for when?

Why a third dose of vaccine?

This week, Pfizer / BioNtech called for a third dose of its vaccine to increase its effectiveness as the highly contagious Delta variant is causing disease outbreaks in Asia and Africa and increasing the number of cases in Europe and the United States. United.

« Preliminary study data shows that a booster dose given 6 months after the second dose has a consistent safety profile, while eliciting high levels of neutralizing antibodies
»Against the virus, including against the Beta variant, appeared in South Africa. These levels are ” 5 to 10 times higher
To those seen after the initial two doses, according to Pfizer / BioNtech.

Is it really necessary?

For laboratories, the economic benefit of a third dose is obvious. But its necessity has not been established. ” Americans who have been fully vaccinated do not need a booster at this time
The US drug agency, the FDA, and the lead federal public health agency, Centers for Disease Prevention and Control (CDC) said in a joint statement. We are ready to give booster doses if and when science shows they are needed », They added.

A study dated June 28 and published in the journal Nature shows that the immune response elicited by messenger RNA vaccines from Pfizer-BioNTech and Moderna could work for several years if it doesn’t mutate too much, notes the New York Times. An opinion shared by researchers from Oxford who believe that ” there is no indication that a recall is necessary », Dated June 29.

For who ?

If the French authorities decide to administer a third dose, they will follow recommendations from the Vaccine Strategy Orientation Council (COSV), in other words ” routine injection of a third dose of vaccine for severely immunocompromised people ».

Are concerned, patients ” dialysés ” and the ” solid organ transplants ” Where ” bone marrow “, As well as people with autoimmune diseases who are undergoing immunosuppressive therapy” strong anti-CD20 or anti-metabolite type »And finally, the French treated for several types of cancer.

The elderly should also be affected by this booster dose. ” When you’re 90, 95, your immune system responds less well. This is why we are considering a vaccination booster at the start of the school year for the elderly in nursing homes. Maybe it will need to be done to boost their immunity », Indicated the Minister of Health, on France info.

This Friday, Olivier Véran added on France Inter: “ What seems to be consensus is a recall in fragile people. »

For when ?

Asked by the Obs this week, Stéphane Bancel, CEO of Moderna, believes that the scenario ” the most careful “Is that of” a third dose for those most at risk, who were vaccinated in December 2020 or January 2021 », From the end of the summer.

For the Orientation Council of the vaccination strategy, the third dose should occur four weeks after the second injection, or “as soon as possible” if this deadline is exceeded. At the beginning of May, the general directorate of health (DGS) confirmed the opinion of the COSV. As pointed out The echoes, severely immunocompromised people can make an appointment for a third injection since May.

Albert Bourla, the leader of Pfizer believes for his part that he ” a third dose is likely to be needed, between six and twelve months (after the first two injections), and then there is a booster each year “. A forecast shared by Alex Gorsky, the CEO of Johnson & Johnson, who also thinks that an annual vaccination will be necessary.


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