▶ ‘This person’ should be taken in the evening
– One study found that there was no significant difference in the effectiveness of high blood pressure medications, whether they were taken in the morning or in the evening.
This is contrary to the findings of some studies that “nocturnal blood pressure”, a predictor of cardiovascular health, decreases when taking high blood pressure medications in the evening.
According to the results of a large-scale clinical study (TIME) conducted by a research group led by Professor Thomas MacDonald of Pharmacology and Epidemiology at the University of Dundee, Scotland, 21,104 hypertensive patients (mean age 65 years, males 58% , Caucasians 98%) on a mean of 5.2 years, hypertension. He stated that the effect of the drug was similar when taken at any time.
The research team randomly divided the study participants into two groups: one group (1503) was given antihypertensive drugs at night (from 8 pm to 12 noon) and the other group (10,601) in the morning (from 6 am to 12 noon). 10). cardiovascular health was followed and observed for an average of 5 years and up to 9 years.
The research team compared and analyzed whether the incidence of cardiovascular and cerebrovascular diseases, such as non-fatal myocardial infarction or cerebral infarction, hospitalization for cardiovascular disease and emergency revascularization, was different between the two groups.
Consequently, 362 people (3.4%) in the group taking the antihypertensive drug at night and 390 (3.7%) in the morning group taking the antihypertensive drug showed no significant difference in the occurrence of these cardiovascular and cerebrovascular diseases. .
Notably, 13 percent of study participants had diabetes and there was little difference between the evening and morning groups of high blood pressure medications. The incidence of falls and fractures related to antihypertensive drug intake was not significant in either group.
These results show that the incidence of cardiovascular and cerebrovascular disease is similar regardless of the time of day the high blood pressure medications are taken, the research team explained.
However, it may be useful to take the antihypertensive drug in the evening for patients with “resistant hypertension” and obstructive sleep apnea, whose hypertension is not well controlled with antihypertensive drugs, the research team added. Regarding the results of this study, Dr. Ryan Tuise, a health researcher at McGill University in Canada, pointed out: “There are patients with ‘nocturnal hypertension’ who have high blood pressure at night, but this study did not bring these patients in account. “
The research findings were presented at the European Society of Cardiology (ESC) 2022 ESC Annual Congress held in Barcelona, Spain. Previously, Professor Ramon Hermida of the University of Vigo, Spain, presented the result of a study at the 2019 ESC annual conference that it is better for the body to take antihypertensive drugs at night than during the day.
Professor Hermida found that 19,000 patients with high blood pressure were divided into two randomized groups for comparison and analysis and found that taking high blood pressure medications while sleeping rather than waking reduced the risk of diseases such as heart attack and stroke.
Half of the patients were asked to take antihypertensive medications at bedtime and the other half as soon as they woke up, followed by a 4 to 8 year follow-up, measuring blood pressure over an initial 48-hour cycle and at least one once a year.
As a result, both groups had similar effects on blood pressure throughout the day. However, the two groups showed significant differences in blood pressure during sleep. Patients taking the drug in the evening had a small but significant decrease in blood pressure during sleep compared to those taking the drug during the day.
Considering age, gender, smoking status, and history of cardiovascular disease, patients taking the drug at night had a 56% lower risk of cardiovascular death, a 49% lower risk of stroke, and a lower risk 44% heart attack compared to those who took the drug during the day.
Medical specialist Kwon Dae-ik journalist>
–
