Vaccination reduces serious complications of COVID-19 in children.
In this study, we analyzed the clinical efficacy of mRNA-based COVID-19 vaccines among Italian children aged 5 to 11 years, using data published by the National Institute of Health. Vaccination status was associated with a reduced risk of COVID-19-related hospitalizations and intensive care unit (ICU) admissions, which were 41% (odds ratio, 0.59; confidence interval [IC] 95%, 0.46-0.77) and 68% (odds ratio, 0.32; 95% CI, 0.04-2.63), respectively, lower in children who completed the vaccination course
In a recent study, Husin and colleagues emphasized the considerable efficacy of the mRNA-based BNT162b2 coronavirus disease 2019 (COVID-19) vaccine against the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. severe in adolescents (Husin et al. al., 2022).
Since not only limiting the burden of SARS-CoV-2 infection, but also preventing the risk of developing serious complications of COVID-19 is imperative in childhood, this study investigated the real effectiveness of vaccination against COVID-19 among Italian children.
The source of our analysis was official data from the Italian Institute of Health (Istituto Superiore di Sanità; ISS) (Istituto Superiore di Sanità, 2022). The official bulletin of the ISS (last update, April 27, 2022) contains periodically updated data at the national level on vaccination coverage, infections related to COVID-19, hospitalizations, admissions to the intensive care unit (ICU) and deaths registered during the previous month at different ages, including the range of 5 to 11 years, stratified by vaccination status.