Louisville vs. Indiana: Expert Picks & Best Bets for Saturday’s College Basketball Clash
INDIANAPOLIS – A Saturday afternoon matchup at Gainbridge Fieldhouse pits the Louisville Cardinals against the Indiana Hoosiers, with Louisville favored by 4.5 points and a moneyline of -190. Analysts are focusing on player prop bets alongside game-level wagers,anticipating a competitive contest with potential for high-scoring performances from key individuals. The over/under is set at 162 points.
This game carries meaning for both programs as they navigate early-season schedules and build towards conference play. Louisville aims to continue its strong road performance against the spread,while Indiana seeks a crucial home win to bolster its resume. Several player props are drawing attention, notably those surrounding Louisville’s Mikel Brown and Indiana’s Lamar wilkerson, with potential to significantly impact betting outcomes.
Game Details:
* Location: Gainbridge fieldhouse, Indianapolis, IN
* Date: Saturday, December 6, 2025
* Tip-off: 2:00 pm ET
* TV: CBS
Louisville vs. Indiana Odds:
* Spread: Louisville -4.5 | Indiana +4.5
* Moneyline: Louisville -190 | Indiana +155
* Over/Under: Over 162 | Under 162
expert Picks & Best bets:
Analysts are highlighting several potential wagers, including a Same Game Parlay (SGP) focusing on individual player performances and game flow:
* Sananda Fru over 6.5 rebounds
* Louisville first half -1.5
* Under 162 total points
* Mikel Brown Over 5.5 assists – Brown is considered the primary offensive initiator for Louisville, making his assist total a valuable prop bet.
* lamar Wilkerson Over 15.5 points – Wilkerson is identified as Indiana’s most likely candidate to score in transition and off-the-dribble.
Betting Trend to Know:
Louisville has covered the spread in 10 of its last 13 road games, achieving +6.7 units and a 47% Return on Investment (ROI).
Key Injuries:
No injuries were reported at the time of publication.
Disclaimer: Odds are correct at the time of publishing and are subject to change. Not intended for use in MA. Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
