https://mundo.sputniknews.com/20210423/hallan-un-compuesto-capaz-de-inhibir-una-proteina-del-cancer-1111505793.html
They find a compound capable of inhibiting a cancer protein
They find a compound capable of inhibiting a cancer protein
It is the compound curcusone D, found in the root of the Jatropha curcas plant, also known as pine nut or jatropha. The chemist Mingji Dai … 23.04.2021, Sputnik World
2021-04-23T12: 38 + 0000
2021-04-23T12: 38 + 0000
2021-04-23T12: 40 + 0000
science
metastasis
Cancer
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The compound curcusone D is capable of inhibiting the BRAT1 protein, which is found in several types of cancers, including: breast, colorectal, lung, prostate, liver, brain cancer, among others. Science considered the BRAT1 protein to be indissoluble until they discovered the compound curcusone D in the root of this plant that is native to America and has spread to other continents, including Africa and Asia, according to Phys.org, adding that there are no other compounds capable of inhibiting the protein BRAT1 cancer; however, this plant does not produce this compound in large volumes so large amounts would be needed to cover an effective treatment. Mingji Dai suggests creating this compound and improving it for future effective cancer treatments. “It would take maybe 100 pounds of the dried roots of the plant to get about a quarter teaspoon of the substance, a 0.002% yield. This is why a new synthesis is so important. We can use the synthesis to produce more compounds in a purer form for biological study, allowing us to advance in the field. From there, we can make analogs of the compound to improve its potency. and decrease the potential for side effects, “concluded Dai.
https://mundo.sputniknews.com/20210330/cientificos-descubren-que-causa-el-tipo-de-cancer-mas-peligroso-1110624456.html
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metastasis, cancer, health
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It is the compound curcusone D, found in the root of the Jatropha curcas plant, also known as pine nut or jatropha. Chemist Mingji Dai, from Purdue University, has discovered a way to synthesize this compound to fight a cancer protein that previously could not be inhibited.
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The compound curcusone D is capable of inhibiting the BRAT1 protein, which is found in several types of cancers, including: breast, colorectal, lung, prostate, liver, brain cancer, among others.
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“Our compound can not only kill these cancer cells, it can stop their migration. If we can prevent the cancer from metastasizing, the patient can live longer,” explained chemist Mingji Dai.
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In addition, he added that there are no other compounds capable of inhibit cancer BRAT1 protein.
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However, this plant does not produce this compound in large volumes, so large quantities would be needed to cover an effective treatment. Mingji Dai suggests creating this compound and improving it for future effective cancer treatments.
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“It would take maybe 100 pounds of the dried roots of the plant to get about a quarter teaspoon of the substance, a yield of 0.002%. This is why a new synthesis is so important. We can use the synthesis to produce more compounds in a purer form for biological study, allowing us to advance in the field. From there, we can make analogs of the compound to improve its potency and decrease the potential for side effects, “concluded Dai.
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