The study opens the door to simplifying chemotherapy for cancer patients

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Cancer treatment is often based on giving Chemotherapy Through the vein, which generates many health consequences and requires the patient to stay in hospital.

However, a study conducted in France on animals and published in a journal "American Chemical Society" It gave hope to simplify the procedure.

But the use of this method, easier to implement and less annoying for the patient, is not possible in most cases because the active components of the treatment tend to stagnate in the subcutaneous tissues, causing necrosis due to its high toxicity.

Scientists have come up with a new approach that aims to overcome this obstacle by binding the poorly soluble active ingredient. "paclitaxel"widely used in chemotherapy, it is a highly hydrophobic polymer.

This made it possible to achieve anticancer drug It is soluble, so it can quickly pass from the subcutaneous tissue into the bloodstream without causing toxicity at the injection site.

During preclinical studies of this new chemotherapy in mice, scientists found that it was more effective than the commercial formulation of the active ingredient Taxol administered intravenously.

The lead author of the study recalled the director of research at the French National Center for Scientific Research (CNRS), Julien Nicolas, in a statement to the agency. "AFP": That "Chemotherapy has many logistical requirements, such as the provision of qualified personnel, hospitalization, etc., and a high cost".

he pointed this out "The main advantage of this new approach lies in facilitation Chemotherapy and improve the comfort of patients who may be able to receive care in their homes".

Although this research has produced promising results on an animal model, its effectiveness in humans has not yet been proven, which prompted scientists to start a company. "Imescia" emerging and I hope to initiate a procedure clinical tests year 2024.

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Cancer treatment is often based on giving Chemotherapy Through the vein, which generates many health consequences and requires the patient to stay in hospital.

However, an animal study conducted in France and published by the “American Chemical Society” gave hope to make the procedure more simplified.

But the use of this method, easier to implement and less annoying for the patient, is not possible in most cases because the active components of the treatment tend to stagnate in the subcutaneous tissues, causing necrosis due to its high toxicity.

Scientists have come up with a new approach that aims to overcome this obstacle by binding the active ingredient which is slightly soluble ».paclitaxel‘, widely used in chemotherapy, is a polymer that is characterized by its strong hydrophobicity.

This made it possible to achieve anticancer drug It is soluble, so it can quickly pass from the subcutaneous tissue into the bloodstream without causing toxicity at the injection site.

During preclinical studies of this new chemotherapy in mice, scientists found that it was more effective than the commercial formulation of the active ingredient Taxol administered intravenously.

“Chemotherapy has many logistical requirements, such as providing qualified personnel, hospitalization and other things, and a high cost,” said the study’s lead author, director of research at the French National Center for Scientific Research ( CNRS), Julien Nicolas, in a statement to the AFP.

He stressed that “the main advantage of this new approach is to facilitate Chemotherapy and improve the comfort of patients who may be able to receive care in their homes ”.

Although this research has produced promising results on an animal model, it has not yet proved effective in humans, which prompted scientists to found the startup “Imescia” and hope to initiate a procedure. clinical tests year 2024.

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