“Until now, technology has not been able to provide such clear answers, but now we know that the vaccine is doing everything we expected, and that’s good news in our fight against the disease,” said David Matthews of Bristol’s Faculty of Cellular and Molecular Medicine, who led the study. effectiveness. “It’s an important study because we were able to confirm that the genetic information that underpins the vaccine, which was developed as quickly as it was safe, behaves correctly when it enters a human cell,” he continued.
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“The study confirms that large amounts of coronavirus S-protein are produced (in the body) with great precision,” Matthews added. The vaccine works differently from the traditional one, using an attenuated or inactivated virus that triggers an immune response in the body that leads to the production of antibodies.
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The vaccine, called ChAdOx1 nCoV-19 and also known as AZD1222, uses only a small sequence of genetic information from the virus, which is introduced into a modified adenovirus that cannot replicate in the body. Information about the S-protein of the virus by which it binds to cells is added. The vaccine in a human cell triggers a reaction that makes copies of the S-protein, making it possible in the body to vaccinate the virus against this S-protein after being vaccinated.
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The study was published on the ResearchSquare server and before the official presentation.
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A placebo volunteer died
Currently, this vaccine is in the last third phase of clinical trials, in which tens of thousands of people are involved. One of them died in Brazil, The Washington Post reported, citing Monday’s announcement by the Brazilian health authority. However, he belonged to the group that received placebo and not the active vaccine, the OGlobo reported. It was a 28-year-old doctor to Rio de Janeiro who took care of those infected with covid-19.
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The last phase of clinical trials looks at how effective the vaccine is and is given to people who come into contact with those infected. But some only get a placebo to make a comparison. Neither the vaccinated nor the doctor who gave him the substance knows whether it was the active substance or a placebo.
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