The onset of collapse begins with the lung. Determine the root cause of severe corona cases

Although the Corona virus is nearing its third year, there are still some things related to it His injuries and deaths are somewhat mysterious. During the three years, Covid-19 has claimed millions of lives and infected hundreds of millions, and so far there remain many questions that do not find satisfactory answers in our minds.

Corona virus has killed more than 6.5 million patients, while more than 620 million people have been infected around the world, according to official statistics, while the real numbers could be much more.

In the latest developments, a research team from a medical school at Mount Sinai Hospital in Manhattan in the United States has identified what they have described as “the leading immune cause of severe Covid-19 cases.”

In a study published in the latest issue of the journal Science Translational Medicine, Translational Medicine ScienceThe research team has meticulously mapped the collapse scenario in severe coronal cases, which begins with the loss of immune cells called “macrophages” that normally live in the lung and regulate tissue repair, followed by the influx of new macrophage cells from the blood in the lung, causing inflammation.

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“Blocking the entry of these inflammation-causing cells and preventing the loss of resident macrophages in the lung may be a therapeutic strategy for treating the disease and other viral lung diseases,” say the researchers, in a report published on the site. Mount Sinai Hospital officer.

During the study, blood and lung fluid samples were collected from healthy controls and 583 COVID-19 patients admitted to Mount Sinai Hospital. Researchers used serum proteins and immune cell phenotyping to compare the two groups’ immune responses and identify potential causes of disease severity that could predict which patients are most at risk and guide new treatment protocols.

The researchers found that the severity of COVID-19 was associated with a change in the specialized functions of various groups of macrophages in the lung, and this may partly explain why older adults, who have fewer compensatory pulmonary macrophages, can produce more inflammatory macrophages. of blood origin. They can be at risk for serious illnessresearchers say.

The researchers pointed out that the study highlights the need to improve immune system measurements in patients.

“Clinically available immunological tests are very limited, which is a shame and must be treated, because understanding the composition of the immune cells that circulate in the blood and the inflammatory molecules they produce can be helpful,” says Mariam Murad, president of the Institute. of Precision Immunology at Mount Sinai Hospital School of Medicine. It is very useful in identifying new treatments for many different diseases. “

“Our study shows that immunophenotyping can help stratify patients based on their aetiology and identify treatment strategies tailored to those causes. In our investigation, a subset of patients would have greatly benefited from the restoration of resident pulmonary macrophages. use of immunoprofilation studies in the clinic would have helped to conduct this intervention early, before disease progression. “

Researchers are now monitoring the covid-19 cohort described in this study to compare the overall immune profile of patients who have long been infected with the virus with those who fully recover, in order to identify drivers and treatment strategies for the virus. prolonged coronavirus infection.

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