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A specific protein cuts the DNA strand
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To prevent the development of glioma, scientists advise taking medications that suppress the expression of the enzyme topoisomerase IIB.
American researchers have identified an enzyme that is involved in the regulation of oncogenes in cells of one of the most common and incurable types of brain cancer – glioma. The corresponding article was published in the journal Clinical Cancer Research.
It was previously found that gliomas exhibit very high expression of the enzyme topoisomerase IIB (TOP2B). This protein cuts the DNA strand and then inserts it back. However, after this, regions of the genome that are located far from each other begin to interact. That allows oncogenes to turn on.
Scientists from Northwestern University analyzed human glioma samples with a genome sequencing method and thus found that the enzyme is present in enhancers and promoters of two glioma oncogenes, PDGFRA and MYC.
It was also found that TOP2B is actively involved in the regulation of the transcription of these genes that provoke the development of a malignant tumor.
The researchers argue that drugs that suppress the expression of the enzyme can help treat glioma.
We will remind, scientists from the University of Edinburgh conducted a successful test a drug that can kill cancer cells… In addition, it does not damage nearby healthy tissue.
A new mechanism of cancer development has been discovered
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