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Health

Title: Blood Reserves Low in Castilla y León – Donate Now

by Dr. Michael Lee – Health Editor November 17, 2025
written by Dr. Michael Lee – Health Editor

Urgent Call for Blood Donations in Castilla y León as⁣ Reserves Dip

Valladolid,Spain – November 17,2025 ⁤- Authorities in Castilla y León are urgently appealing⁢ to residents to ​donate‍ blood as ⁢regional reserves reach critically low levels,possibly impacting scheduled surgeries⁢ and ⁣essential medical procedures. The shortfall poses a significant‍ risk to hospital operations reliant on⁣ a⁤ consistent blood supply.

Castilla y León has historically been a region known for its strong donor participation, but current levels are insufficient to meet ongoing needs. The situation is notably concerning as the approaching winter months typically see a decline in donations. A stable blood supply is⁤ vital⁢ for treating trauma victims,‌ supporting cancer patients, and ‍ensuring the success of a wide range of surgical interventions. Health officials emphasize that maintaining adequate reserves is⁣ crucial to avoid compromising patient care.

Individuals between the ages ⁤of 18 and 65 who weigh over 50 kilograms and are in good health are eligible to donate. Potential donors must⁣ not have any blood-transmissible diseases, including⁢ Hepatitis B or C, AIDS, or syphilis. A minimum of two​ months must ⁤pass between‍ donations; women‍ are eligible to donate up to three times per year, while men can donate up to four.

The Hemotherapy and Hemodonation Center of Castilla y León encourages anyone meeting ‍the criteria to⁤ donate as soon as possible to help replenish dwindling supplies and safeguard the​ region’s healthcare system. ‌Information ‍on donation locations and⁤ eligibility requirements can be found at https://cadenaser.com/castillayleon/2025/11/17/deficit-en-los-niveles-de-sangre-en-castilla-y-leon-se-pide-ir-a-donar-lo-antes-posible-radio-valladolid/.

November 17, 2025 0 comments
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Health

Gene Therapy Halves Bad Cholesterol, Offers Potential for Lifelong Treatment

by Dr. Michael Lee – Health Editor November 17, 2025
written by Dr. Michael Lee – Health Editor

Single Infusion May Offer Lifelong Cholesterol Control

Table of Contents

  • Single Infusion May Offer Lifelong Cholesterol Control
  • Initial ‍Trial Shows promising Results
  • Safety is a​ Priority, ⁢Long-Term Monitoring Planned

Scientists ⁢have successfully ⁣tested a new gene therapy that dramatically lowers “bad” cholesterol with a single infusion, ⁣potentially offering a lifelong solution for those struggling to manage their levels. The experimental treatment works by permanently altering DNA within liver cells.

The therapy targets a specific gene⁤ responsible for regulating fats ​in the bloodstream. By permanently disabling this ‍gene, the body⁢ is⁢ better able to break down and​ clear ⁢fats. This approach is inspired by individuals ⁢born with a natural defect in this same gene, who experience lifelong low cholesterol and a reduced risk of heart disease without apparent‍ harm.

Initial ‍Trial Shows promising Results

A first-in-human study involved 15 ⁢patients with ⁢persistently high cholesterol despite already⁣ being on strong medication. ‍Participants received varying⁤ doses⁢ of the gene therapy via intravenous infusion.

Results showed a significant⁤ reduction in cholesterol levels at the⁤ highest‌ dose: “bad” cholesterol (LDL) ‌fell by ⁣nearly 49% and triglycerides by 55% just two months after treatment. The protein that hinders fat breakdown decreased by over ⁣70%.Early indications suggest these effects are lasting, though⁣ longer-term monitoring is crucial ‌to confirm ‍the ⁤permanence of ⁣the change.

The technology utilizes​ CRISPR-Cas9, frequently enough described as “molecular scissors,” to ‌precisely cut and modify DNA. The treatment delivers ‍instructions encased in fat globules, which are absorbed by liver cells and then used to switch off the target gene.

Safety is a​ Priority, ⁢Long-Term Monitoring Planned

The ‍primary focus of this initial study was safety. Side​ effects were minimal. Three participants experienced mild reactions like back pain and nausea during the infusion, which resolved with a ⁢temporary pause. One participant had a temporary increase in liver enzymes that returned to ‍normal within ⁣two weeks. Importantly,⁤ a death occurred 179 days after treatment at ⁤the lowest dose,​ but was determined to be unrelated to the therapy.

Researchers⁤ emphasize the small size of the study and the limited follow-up period. Given the‌ permanent nature of the DNA modification, participants ​will be monitored for up to​ 15 years to identify any potential long-term effects. Larger studies are needed to definitively establish the ‍treatment’s safety and⁣ confirm its lasting efficacy.

Source: The New England Journal of Medicine

November 17, 2025 0 comments
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Health

Title: Britain’s Obesity Crisis: Drugs, Cost, and Systemic Solutions

by Dr. Michael Lee – Health Editor November 17, 2025
written by Dr. Michael Lee – Health Editor

Weight-Loss Drug Debate Intensifies as Britain Grapples with Obesity Crisis

london – As Britain faces a growing obesity crisis, a debate is escalating over the role of pharmaceutical interventions like Ozempic alongside systemic changes to ⁢food access⁣ and societal attitudes.Experts ​and individuals impacted by obesity are calling for a multi-faceted approach, moving beyond individual blame and addressing the complex‍ factors contributing to‍ the nation’s weight problem.

The discussion comes amid‌ rising⁣ obesity rates and⁢ increasing interest in drugs initially developed ‍for diabetes, now being used off-label⁢ for weight loss. While some hail these medications as ‍”transformational,” others emphasize the need for broader solutions targeting the food environment ​and dismantling the stigma surrounding obesity. This confluence of perspectives was highlighted in recent conversations with advocates and those directly affected.

Raine, an‌ advocate for systemic change, proposes taxing unhealthy foods to subsidize healthier options, arguing against reliance on voluntary improvements from the food industry.”People are very quick to make statements about how people should live without really understanding how people have to live. It’s not just about reducing poverty. It’s also about enabling people to make healthy choices – and that’s a system-wide issue,” she stated.

Le ​Brocq,who has experienced a significant positive impact from weight-loss drugs,simultaneously calls for pressure on food companies to invest in⁣ healthy,palatable alternatives and for government intervention to ensure equitable access to nutritious food across all communities. She also⁢ stresses a critical shift in societal perception.

“We need to talk more about the stigma and ‌the fact that we don’t recognise obesity⁤ as a chronic condition. We‌ still treat it as a lifestyle condition,as if people just made bad choices,but we know now that’s not the ‍case,” Le Brocq explained. “We need to be kinder to people and have ⁤more empathy for people and⁢ actually support them, rather than⁤ pointing fingers of ‍blame. I’ve ⁢spent my whole life trying to sort myself out as nobody wanted to help ⁤me. We need to change that and support people now that there ⁢are options available‌ for⁢ them.”

The debate⁢ underscores the complexity of ⁤tackling obesity in Britain, where a combination of pharmaceutical advancements, systemic reforms, and ⁤attitudinal⁢ shifts might potentially ⁤be necessary to address the crisis effectively.

Readers can share their stories and opinions with The Big Issue here.

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November 17, 2025 0 comments
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Health

Title: New Cholesterol Pill Could Slash Heart Attack Risk

by Dr. Michael Lee – Health Editor November 17, 2025
written by Dr. Michael Lee – Health Editor

New ​Oral Drug Dramatically Lowers Cholesterol, Offering Potential Choice to‌ Injections

São Paulo, Brazil – November 16, 2025 – In a potential breakthrough for cardiovascular health, pharmaceutical company Merck has developed an oral medication capable of reducing “bad” cholesterol (LDL) ⁣to‍ remarkably low⁢ levels, offering a possible alternative to costly and inconvenient ⁣injectable drugs. The pill targets PCSK9,‍ a⁢ protein that​ prevents the ‌liver from removing LDL cholesterol⁢ from the blood.⁤

For years, lowering LDL cholesterol has relied heavily on ​statins, but many patients require additional ​therapies to reach recommended levels. Current options⁤ often involve PCSK9 inhibitors, which⁣ are administered via ⁣injection. ​Merck’s new drug, enlicitid, represents a meaningful step towards a‌ more accessible and affordable⁢ treatment.

The challenge in creating a ‍pill-form PCSK9 inhibitor lay in the size‌ of the‌ molecule. ⁣Conventional small-molecule drugs are easily absorbed, but PCSK9 inhibitors are large‌ proteins.”Getting a ‍large‌ molecule like those in most pills, would be very small,” explained researchers.‌ Merck’s​ solution, after a⁣ decade of ‌research, involved creating a circle of peptides – one-hundredth the ⁤size ⁢of‍ an antibody but larger than a​ typical small⁤ molecule.

“This method could allow researchers ⁢to create pills that could⁤ replace many other injectable medications,” stated Dean⁢ Li, president of Merck Research Laboratories. He‍ emphasized the ​economic benefits, noting that pills ⁤are cheaper to manufacture and transport than injectables, which require refrigeration. Merck aims to ⁢price enlicitid competitively, making⁣ it widely available in the United States and globally, envisioning ‍a future where taking the ​pill is “no different than⁣ aspirin” or standard ⁤blood pressure medication.

“The dream is to democratize PCSK9,” ​Li‌ said. ⁢”This dream has the possibility of becoming reality.”

Cardiologists are optimistic about the ⁤potential impact. “It could be a game changer,” said​ Christopher Cannon, a cardiologist at⁢ Brigham and Women’s Hospital in Boston, who is not affiliated with Merck. David Maron, ‌a ‌preventative ⁣cardiologist at ⁢Stanford‍ University, added, “If they price ‍this so people⁣ can afford it, it will make a huge difference” for the millions at risk‍ of heart attacks and strokes.‌ “This is a really crucial advance.”

AstraZeneca is also developing a ⁤PCSK9 pill, according to Maron, who is involved​ in monitoring the safety of⁢ these drugs in clinical trials.

Merck is⁤ currently conducting‍ a‌ large-scale study involving over 14,500 ⁢participants to ⁣confirm that lowering LDL cholesterol with⁣ enlicitid translates into fewer‌ heart attacks,strokes,and cardiovascular deaths. The company ‍plans to submit the drug for U.S. food and Drug Administration approval in early 2026, with an⁢ anticipated launch in⁣ 2027.

November 17, 2025 0 comments
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Health

Title: New Obesity Treatments Offer Hope, But Require Broader Solutions

by Dr. Michael Lee – Health Editor November 17, 2025
written by Dr. Michael Lee – Health Editor

Summary of the Article: Obesity – A ‌Focus on Prevention Over Cure

This article argues that the current approach to obesity, heavily focused ​on⁢ treating the condition once established (frequently enough with expensive drugs like GLP-1 analogues), is fundamentally flawed.It contends that prevention is not only more effective ⁤but​ also more cost-effective ⁢in the long run. The author criticizes⁢ the prevailing⁤ narrative that places the onus of duty ‍on individual behavioral changes (“healthy-dietary measures”) while largely ignoring the systemic factors that contribute to obesity.

Key Arguments:

* Current “Prevention” is Insufficient: The article challenges the ​assumption⁢ that simply advising individuals to eat healthier and exercise is enough. It questions the⁢ methods used to develop thes⁢ “healthy-dietary” measures and the ⁤lack‌ of attention paid to barriers to implementation.
* Systemic Factors Drive Obesity: The author ‍outlines ​numerous factors beyond individual⁢ choice that contribute​ to obesity, including:
* Easy Access to Unhealthy Foods: Cheap, heavily advertised, ultra-processed foods are readily available.
‌* Political &⁣ Economic Obstacles: Implementation of helpful tools like Nutri-score is hindered‍ by economic interests.
⁤ * Environmental Pollutants: Exposure to⁤ pollutants can promote obesity through hormonal disruption.
* Poor Urban ‍Planning: Lack of infrastructure⁢ for active mobility and ‍physical activity.
‌ * Socio-Economic Disparities: Poverty, precariousness, and social inequalities significantly impact health and contribute to higher obesity rates (e.g., 17% obesity ⁣rate in the lowest income quartile vs.10% in the highest in France).
* cost of Treatment: New drugs like GLP-1 analogues are expensive (around €300/month) and ‍potentially inaccessible to many without insurance coverage. ‌widespread use, even with insurance, could be financially unsustainable⁣ given the projected rise in obesity rates.
* Multidisciplinary Approach is Crucial: ⁤ The author advocates for a extensive,⁤ multidisciplinary approach combining scientific knowledge with the lived experiences of patients, health professionals, and policymakers.
* Public Health Over ‍Short-Term ​Profits: Addressing obesity effectively requires public health policies that prioritize⁢ health ⁣over short-term economic gains.

In essence, the⁣ article is a call ​for a paradigm shift – from focusing on ⁤expensive, individual-level treatments to investing in broad, enterprising public health policies that address the root causes of obesity and promote health equity. ⁣ It ⁢emphasizes that prevention, while less “spectacular” than new therapies, is essential ⁢for a enduring solution.

November 17, 2025 0 comments
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Health

Title: 3 Types of Hair Loss & Effective Treatments: What Dermatologists Recommend

by Dr. Michael Lee – Health Editor November 16, 2025
written by Dr. Michael Lee – Health Editor

Emerging Treatments Offer Hope in Fight Against Hair Loss, But Success varies

São Paulo, Brazil ​- November 16, 2025 – Millions grapple wiht hair loss, a condition often linked to genetics but increasingly addressed with a growing arsenal of medical and cosmetic⁢ interventions.While a worldwide cure remains elusive, dermatologists are finding success with specific treatments tailored to different types of hair loss, though patient outcomes vary significantly. Understanding the underlying cause of hair loss is crucial, as treatments effective for one type may be​ useless for another.

Hair loss manifests in several forms. Androgenetic alopecia, commonly known as male or female pattern baldness, is the‍ most prevalent, affecting both sexes and characterized by a gradual ​thinning of hair. ‍Alopecia areata is an autoimmune condition causing⁣ patchy hair loss,while telogen effluvium results from‌ stress or physiological changes,leading to widespread ‌shedding. “In the simplest⁣ terms, the hair follicles on the scalp are either⁢ intact – and hair can grow back – or they have ⁢been destroyed,” explains Antonella Tosti,‍ a professor of dermatology at the University⁣ of Miami. ​

For androgenetic alopecia, medications like finasteride, traditionally used for men, are increasingly being prescribed off-label for women, though ‍with less ⁤extensive study, according to Dr.Goh. ‌ Finasteride can cause⁤ sexual side effects, but dermatologists like Lipner⁣ note that the benefits can ⁢outweigh‍ the risks for some patients. Another option, spironolactone, an antiandrogen ⁤medication, ⁤is also used off-label for younger women, Dr. Goh adds.

Beyond medication, ‍dermatologists⁣ are employing complementary procedures to boost effectiveness. These include platelet-rich plasma (PRP) injections and ​low-frequency red ⁣light therapy, as highlighted by Mirmirani. Though, these treatments typically require six months to a year to demonstrate ⁤results.

When hair follicles ‌are irreparably ​damaged, a hair transplant – moving follicles from ​one scalp area to another – ⁤may be the only solution. ‌Lipner cautions, “But keep in mind that⁣ hair transplants aren’t simple either,” ‌and require ongoing medication to maintain results.

Despite the proliferation of products promising hair regrowth, some treatments lack robust scientific backing. Biotin supplements, frequently marketed for healthy hair, have shown little evidence of effectiveness unless a patient has a rare ‌biotin ​deficiency, ‍Lipner states. Furthermore, high doses of⁢ biotin can interfere with ‍certain laboratory tests,⁤ including those ‍used to diagnose heart attacks, prompting Lipner to advise patients to ‍avoid them. Goh emphasizes the lack of regulation surrounding supplements and cosmetic products, noting they don’t undergo the⁣ same rigorous safety standards as ​pharmaceuticals.

Experts⁢ recommend prioritizing healthy lifestyle habits – regular exercise, improved nutrition, and sufficient sleep – before turning ⁤to supplements or multivitamins. “Genetics are hard to prevent,” Mirmirani says, “But the things you can change are these healthy habits.” For pregnant ‌women experiencing hair loss, there are currently‍ no safe⁢ treatment options available.

November 16, 2025 0 comments
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