In scientific research, hair loss seems to be classified as a cosmetic rather than a medical problem. Maksim Plikus, a cell biologist at the University of California, Irvine, said: “A person will not die from hair loss. But hair is actually a part of the body and identity, and hair loss can have a huge impact on mental health. Even in some research reports: Cancer Patients refused treatment because chemotherapy caused hair loss.” Before earning his doctorate in pathology, Plikus practiced at a hair transplant clinic and started his own lab specializing in hormone-related hair loss. In studies of androgenic baldness in men, it was found that the stem cells of the hair follicles were in a “dormant” state, meaning they simply stopped producing new hair. Thick hair will gradually thin, fall out more easily, and eventually disappear. “The process is actually quite subtle, and most people don’t think it’s that complicated,” Plikus said.
Key new discoveries for hair loss
Right now, there are few options for treating hair loss. Using two drugs to slow or stop hair loss has little effect on hair regrowth, and the effect wears off when the treatment is stopped. Another option for treating hair loss. Instead, the hair follicles are transplanted from the back of the head to the top through surgery, but this only disrupts the existing hair. The Plikus lab is exploring not just the mechanisms of hair loss, but aging itself. One of Plikus’ odd quirks is to investigate hairy moles—hairy moles—on the chest, arms, or other body parts that grow hairs even though the skin around them is hairless. For the past 10 years, Plikus’ team has delved into why hair grows here, primarily in hopes of finding a protein that could do the same for the scalp. Now they’ve found it, he said: a protein called osteopontin.
Darren Robb
Hairy mole can solve hair loss problem?
In the June issue of “Naturein Nature』In a series of experiments reported in the journal, the team found that osteopontin promotes hair growth in mice. In one test, the team achieved the same effect by transplanting human hair into mice. This has clear implications for hair regrowth, but it also raises some interesting questions about senescent cells. The osteopontin in moles comes from cells that appear to be senescent, which are not dead but are no longer dividing. Aging is protective because it prevents mutations in cells from proliferating into cancer. Aging researchers have long thought that these old cells stick to their surroundings, damaging the younger cells around them. When they stop replicating, they may contribute to age-related diseases by secreting harmful molecules and increasing inflammation and dysfunction.
Aging plays a key role in the formation of moles: mutated pigment-producing cells called melanocytes stop replicating to prevent themselves from turning into aggressive cancer cells. But something in their environment causes the tiny hairs in the surrounding follicles to grow so long and thick that they continue to grow even when other cells don’t. “I became fascinated by the exact opposite of what you see in a mole versus what you see on the scalp of a balding person,” Plikus said. Plikus was surprised to find that senescent melanocytes could produce effective regeneration Agents, which are supposed to lie dormant, apparently promote healthy growth, if not harmful. He demonstrated that under certain conditions, molecules secreted by these senescent cells are beneficial for hair growth.
2023-07-14 03:31:37
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