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(Taiwan English News / Zhu Mingzhu comprehensive foreign report) According to a study published in the journal “The Lancet”, researchers have found a particularly severe monkeypox (Mpox) virus in patients with advanced HIV, which not only has a higher fatality rate , and easily lead to serious complications.

Before April of last year (2022), monkeypox epidemic areas were mainly in West and Central Africa, but since the first local case appeared in the UK on May 7 last year, it has spread rapidly around the world, and the vast majority of infected people are people of the same sex Men who have sex, as of now, at least 110 countries have reported more than 86,000 confirmed cases and 93 deaths; 38-50% of these confirmed cases are also HIV-infected, but most of them are receiving anti-AIDS virus treated and in stable condition.

An international team of clinicians from 19 countries analyzed 382 cases of monkeypox and advanced HIV infection, including deaths at the peak of the epidemic, between May 11, 2022, and January 18, 2023. 27 people with monkeypox.

Researchers have identified a particularly severe form of monkeypox (Mpox) virus in patients with advanced HIV and named it “violent monkeypox virus”, which can cause severe symptoms such as extensive sores on the skin and genitals, and even death. Extensive necrotic lesions in the lungs; the most severe symptoms are usually seen in patients with the lowest counts of white blood cells called CD4 cells.

CD4 cells refer to T lymphocytes with CD4+ T molecules on the surface, which are important immune cells in the human immune system. The CD4 cell number index of normal people is about 800-1200 cells/mm3, but when the HIV virus enters the human body, it will It is carried to the whole body through the blood and destroys CD4 cells in the human immune system. According to the US Centers for Disease Control and Prevention (CDC), HIV infection is diagnosed when the CD4 count is below 200.

Epidemiologist Oriol Mitja called on health authorities to give priority to monkeypox vaccination for “people infected with HIV”, especially in countries where diagnosis and antiviral treatment are not widely available. Chloe Orkin, professor of clinical medicine at Queen Mary University of London, suggested that monkeypox patients should be tested for HIV, and if HIV-infected people are infected with monkeypox, CD4 values ​​must be tested.

Study: HIV-infected people found to be at higher risk of complications, death from violent monkeypox virus

(Taiwan English News / Zhu Mingzhu comprehensive foreign report) According to a study published in the journal “The Lancet”, researchers have found a particularly severe monkeypox (Mpox) virus in patients with advanced HIV, which not only has a higher fatality rate , and easily lead to serious complications.

Before April of last year (2022), monkeypox epidemic areas were mainly in West and Central Africa, but since the first local case appeared in the UK on May 7 last year, it has spread rapidly around the world, and the vast majority of infected people are people of the same sex Men who have sex, as of now, at least 110 countries have reported more than 86,000 confirmed cases and 93 deaths; 38-50% of these confirmed cases are also HIV-infected, but most of them are receiving anti-AIDS virus treated and in stable condition.

An international team of clinicians from 19 countries analyzed a total of 382 cases of monkeypox and late-stage HIV infection, including those who died at the peak of the epidemic, between May 11, 2022, and January 18, 2023. 27 people with monkeypox.

Researchers have identified a particularly severe form of monkeypox (Mpox) virus in patients with advanced HIV and named it “violent monkeypox virus”, which can cause severe symptoms such as extensive sores on the skin and genitals, and even death. Extensive necrotic lesions in the lungs; the most severe symptoms are usually seen in patients with the lowest counts of white blood cells called CD4 cells.

CD4 cells refer to T lymphocytes with CD4+ T molecules on the surface, which are important immune cells in the human immune system. The CD4 cell number index of normal people is about 800-1200 cells/mm3, but when the HIV virus enters the human body, it will It is carried to the whole body through the blood and destroys CD4 cells in the human immune system. According to the US Centers for Disease Control and Prevention (CDC), HIV infection is diagnosed when the CD4 count is below 200.

Epidemiologist Oriol Mitja called on health authorities to give priority to monkeypox vaccination for “people infected with HIV”, especially in countries where diagnosis and antiviral treatment are not widely available. Chloe Orkin, professor of clinical medicine at Queen Mary University of London, suggested that monkeypox patients should be tested for HIV, and if HIV-infected people are infected with monkeypox, CD4 values ​​must be tested.

Study: People with advanced HIV infection are at higher risk of complications, death from monkeypox

Rockville, MarylandFebruary 16, 2023 /PRNewswire/ — Tetracore, Inc. (Tetracore®) is pleased to announce a partnership with the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) to provide Large supply of PCR kits. These kits were purchased for use in the National Animal Vaccines and Veterinary Countermeasures Library to ensure that the United States is prepared for a possible outbreak of severe exotic animal disease (FAD). As the only PCR kits authorized by the USDA for use with these diseases, Tetracore’s VetAlert African Swine Fever and Hand, Foot and Mouth Disease Diagnostic Tests are critical to minimizing the potentially devastating impact of exotic animal disease outbreaks.

The emergence of African swine fever in the Dominican Republic represents an imminent threat to the welfare of US food production. Outbreaks of hand, foot and mouth disease and African swine fever can have devastating economic consequences for the livestock industry. This threat requires readily available, accurate and validated diagnostics. The immediate surge of samples flooding animal health testing laboratories will quickly exhaust available countermeasures. To address the need for laboratory surge capacity in the event of an outbreak, the USDA has asked Tetracore to stockpile its USDA-authorized HFMD and ASF test kits.

The VetAlert ASF and HFMD Diagnostic Tests have been updated with modern viral sequences to ensure the tests remain fit for purpose. These assays have been validated in studies in multiple reference laboratories. The VetAlert™ African Swine Fever and Hand, Foot and Mouth Disease Diagnostic Assays were developed and commercially marketed by Tetracore scientists and are sold exclusively by Tetracore.

About Tetracore, Inc.

Tetracore is a biotechnology company that develops and manufactures diagnostic instruments and assays for the detection of infectious diseases. The company is located in the Biotechnology Corridor of Rockville, Maryland. Tetracore was founded in 1998 by former United Nations Special Commission biological weapons inspectors and scientists at the Naval Medical Research Institute in Bethesda, Maryland. For more information, please visit or send email to contact us.

®Tetracore is a registered trademark, and VetAlert yes Tetracore, Inc. the trademark of

(Life Center/Comprehensive Report) Modern people live in a tight pace, are busy with work and cannot eat a balanced diet. Insufficient intake of key body nutrients is a common national health problem. According to a survey by the National Health Service, Taiwanese The lack of calcium intake is quite serious. More than 90% of people have an average daily intake of only about 600 mg, which is far below the recommended daily intake of 1000 mg by the National Health Service. Calcium deficiency is a major health concern. In addition to directly leading to osteoporosis and possible problems with the heart, eyes and skin, this situation is caused by eating too little calcium-rich food and not choosing the right calcium absorption. Food with a high rate is also a very important reason.

Picture / left to right (Mrs. Emma, ​​Principal Zhongting, Teacher Xiao Lai, Nutritionist Gao Minmin, Lin Linma, Yongfengyu Frank).

I once encountered a real case where a mother took her child to climb a mountain, but the adult suffered a fracture herself. This also made Gao Minmin, who is known as the most beautiful nutritionist, realize that calcium deficiency can be said to be the health link that Taiwanese families most need to improve. Gao Minmin has long been concerned about the issue of Chinese people’s health and nutrition balance. As a well-known KOL “Gao Minmin Nutritionist” on the Internet, she continuously shares nutrition and health information and teaches the public correct knowledge; Loved by many fans, the popular nutritional lazy bag series has tens of millions of hits every month. For the common health problem of calcium deficiency, it is already the role of a mother of two children, and even more so. Let it invest a lot of time and energy to develop foods that can truly and effectively supplement calcium nutrition for the people.

The happy calcium element META Ca, which won the SNQ national quality label this time, is a high-quality nutritious food developed by nutritionist Gao Minmin sincerely. It especially uses Irish red algae calcium, French vitamin D, Dutch vitamin C and Norwegian microencapsulated vitamins. K2 provides nutrients. Dietitian Gao Minmin happily expressed that the affirmation of the SNQ national quality label made him feel that he is on the right path and doing meaningful things through the nutrition profession. It has always been our goal to help Chinese people move towards a better quality of life, and it is great to see this vision become a reality.

Figure/Meta Calcium won the SNQ National Quality Mark of the 25th National Biotechnology and Medical Quality Award.

At the same time, nutritionist Gao Minmin is also diversifying into multi-faceted industries such as Bella Plastic Surgery, MinVita 100-calorie Meal, 100-calorie Porridge, and Innovative Joint Brokerage Company, hoping to help people in need in more comprehensive aspects of life in the future, grasp Nutrition, maintaining health, creating beauty and having the happiness and beauty you pursue.

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(Taiwan English News/Comprehensive report by Zhu Mingzhu)The latest research in the United StatesHigher vitamin D supplementation in adults with “prediabetes” was found to be associated with a lower risk of developing type 2 diabetes. The study was published in the “Annals of Internal Medicine” on the 7th.

In order to assess whether taking vitamin D can reduce the risk of diabetes in patients with “pre-diabetic symptoms”, researchers from Tufts Medical Center in Massachusetts, USA, recruited 4190 adult subjects and randomly assigned them After 3 experimental groups and 1 control group, clinical trials were carried out for 3 years.

According to the study report, a total of 2,097 adults were included in the experimental group (taking vitamin D), of which 475 had “pre-diabetic symptoms”; two groups used inactive vitamin D3, and the other group used active vitamin D. Of the 2,093 people in the control group (taking a placebo), 524 had “prediabetic symptoms.”

The results of the mixed analysis showed that compared with the placebo group, the vitamin D supplementation group reduced the relative risk of diabetes by about 15%, and the absolute risk was reduced by 3.3%, even allowing patients with abnormal blood sugar to return to normal blood sugar.

So the study authors estimated that, when extrapolating their findings to the more than 374 million adults with “prediabetes” worldwide, vitamin D supplementation could delay the onset of diabetes in more than 10 million people.

In this regard, Li Tingwei, director of the Metabolism Department of the Department of Internal Medicine of Wanfang Hospital, Ou Hongyi, director of the Diabetes Prevention Center of Chengda Hospital, and Xie Boxuan, professor of Physiology and Biophysics at the National Defense Medical College, all put forward their analysis. Experts pointed out that the study used high-dose vitamin D, which is not suitable for ordinary people, and high-dose vitamin D may increase the risk of hypercalcemia, hyperuria or kidney stones.

Ou Hongyi said that although the results of the study pointed out that only in groups with low or insufficient blood vitamin D levels, vitamin D supplementation can have the benefit of preventing “pre-diabetes” from progressing to diabetes, but he reminded that in the study, vitamin D supplementation was seen in patients Afterwards, the average blood levels achieved were higher than the generally recognized safe range, and even reached the levels considered “possibly harmful” in the past. In terms of blood sugar balance, it is necessary to consider what the reasonable concentration of vitamin D is.

Xie Boxuan said that the subjects of the study were patients “with pre-diabetic symptoms”, rather than results that the general public can refer to. Therefore, this study does not prove that vitamin D supplementation in the general public can effectively reduce the risk of diabetes.

In addition, the pre-diabetic patients in the study used vitamin D doses up to 1200 international units (IU) and maintained a high blood vitamin D concentration, which seemed to reduce the incidence of diabetes, but long-term use could easily cause hypercalcemia and hyperhemuria, etc. related toxic reactions.

Xie Boxuan added that the recommended daily dietary dose of vitamin D is 400 to 600 international units (IU), and this dose range cannot reach the dose that effectively reduces the incidence of diabetes in the research.

Li Tingwei pointed out that the study analyzed active and inactive vitamin D together. He felt a little doubtful, because inactive vitamin D3 can be used as a nutritional supplement for the general public, but active vitamin D is prescribed by doctors. dangerous, it is recommended to consult a professional physician first.

Finally, Hongyi Ou concluded that although the research provided scientific evidence that vitamin D can prevent “pre-diabetes” from progressing to diabetes, the benefits are limited to strictly screened “pre-diabetes” patients, not the general public. Therefore, he suggested that the general public does not need to rush to supplement vitamin D, and let more research reports in the future verify these results and safety.

※Source: Taiwan Technology Media Center※

American study says vitamin D can prevent diabetes Experts remind: Excessive use may increase the risk of hypercalcemia and hyperuria