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A new study in Science Advances suggests that the customary focus on A-beta and tau amyloids in Alzheimer’s research might be too narrow. Researchers studied rats and found over 200 types of misfolded proteins, beyond amyloids, that are associated with age-related cognitive decline. These misfolded proteins, even when not forming clumps, appear to impair brain function. the study highlights that amyloids may only be a small part of the problem,and these other misfolded proteins could be escaping the cell’s natural surveillance system. this discovery opens up potential new therapeutic targets for Alzheimer’s, dementia, and other age-related cognitive diseases, offering hope for better treatments and preventive measures. The next step for the researchers is to examine these misfolded proteins at a higher resolution to understand their molecular deformities.
