Study: The Covid-19 Vaccine Remains Effective Against Mutations of SARS-COV-2

TEMPO.CO, Canberra – A study conducted by Australia’s national science institute found that viral mutations did not affect effectiveness the Covid-19 vaccine potential.

A study published by the Commonwealth of Scientific and Industrial Research Organization (CSIRO) on Thursday, October 8, 2020, dismissed concerns over the possibility that vaccines could be ineffective against various strains. SARS-CoV-2, the virus that causes Covid-19.

According to the study, most vaccine candidates are based on the D strain of the virus that was dominant when the pandemic broke out.

However, the virus has developed into the G strain or the D614G mutation, which now accounts for 85 percent of the SARS-CoV-2 genome.

The CSIRO team tested the two strains of the virus on civet blood that had been vaccinated with INO-4800, a vaccine candidate developed by Inovio Pharmaceuticals, and found that the vaccine was still effective against both D and G strains.

“This brings the world one step closer to a safe and effective vaccine to protect communities and save lives,” said Larry Marshall, Chief Executive of CSIRO, in a statement.

“Research of this kind is only possible quickly through in-depth collaboration with partners both in Australia and around the world,” he continued.

The study’s lead author, SS Vasan of the CSIRO Dangerous Pathogens Team, said the findings were good news for the hundreds of vaccines currently being developed around the world.

“The majority of Covid-19 vaccine candidates target the virus spike protein because it binds to the ACE2 receptors in our lungs and respiratory tract, which are the entry points for infecting cells,” said Vasan.

“Despite the mutation of D614G into the spike protein, we have confirmed through various experiments and modeling that vaccine candidates are still effective.”

“We also found that the G strain most likely did not require a ‘matching vaccine’ when vaccine new ones need to be developed seasonally to combat various strains of the virus in circulation, as is the case with influenza, “he added.



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