Broken heart syndrome occurs when the heart muscle suddenly becomes weak and the left ventricle of the heart changes shape. Scientists were amazed by the biological triggers of Takotsubo syndrome, which they linked to the -16 and -26a microRNAs that regulate how genes are decoded and activated during stressful times, according to the Daily Mail.
These molecules are linked to depression, anxiety and stress, suggesting that long-term suffering, followed by a dramatic shock, could trigger the syndrome. The study was published in the journal Cardiovascular Research AFP.
In fact, according to the quoted source, the symptoms are similar to those of a heart attack and include chest pain, heavy breathing, which can eventually lead to cardiac arrest.
“Takotsubo syndrome is a serious condition, but so far the way it appears has been a mystery. We do not understand why some people respond in this way to a sudden emotional shock, while others do not. This study confirms that previous stress and its associated microRNAs may predispose a person to the development of Takotsubo syndrome in future stressful situations. Stress comes in many forms and we need more research to understand these chronic stress processes, ”said Professor Sian Harding of Imperial College London.
There are currently no treatments to prevent the recurrent onset of broken heart syndrome, but the results of this study could help create new treatment options to prevent further deaths.
“Takotsubo syndrome is a sudden and potentially catastrophic heart problem, but our knowledge of its causes remains limited. As such, it is vital that we learn more about this neglected condition and develop new ways to prevent and treat it. This research is not only a crucial step towards a better understanding of this mysterious disease, but could also provide new ways to identify and treat those at risk for Takotsubo. We now need further research to determine whether drugs that block these microRNAs could be the key to preventing broken heart syndrome, “said Professor Metin Avkiran, associate medical director at the British Heart Foundation.
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