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Study: Perfusing ‘young’ blood does not prolong life

In a new study, young and old mice were surgically linked so they shared the bloodstream for three months. According to the results, the aged mice had no apparent advantage in terms of longevity. On the other hand, young mice exposed to the blood of older animals had a significantly shorter lifespan than mice that shared blood with other young mice. The research was published July 22 in the journal Rejuvenation Research.

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Heterochronic parabiosis is a research tool used to assess the effects of organ and blood borne factors in young and old animals. Xenosymbiosis, a form of blood exchange between two surgically linked animals, is less controlled than direct exchange transfusion. Iryna Pishel and collaborators from Taras Shevchenko National University in Kyiv, Ukraine and Bienta Ltd. and co-workers used allochronous xenobiotic exchange between young and old mice for three months. They then separated the animals and studied the effects of the compound on the animals’ plasma and longevity.

“The most powerful and interesting result of this study is the fact that young mice with heterochronic xenobiosis have a significantly reduced lifespan,” the researchers noted. Factors of aging.” They concluded, “Locating and selectively inhibiting the production of aging factors in the body may be a key area of ​​lifespan extension research.”

Irina Conboy, Ph.D., a professor at the UC Berkeley School of Engineering, said, “This work resolves the long-debated question of whether young or old blood controls lifespan. Whether metachronous xenobiotics have lasting effects when rejuvenating or aging?” Pishel’s group’s work found that old mice did not have longer lifespans after allogeneic experiments with young mice. Conversely, young animals that mated with older mice had shorter lifespans even after they were separated.

“This finding is important for setting the precise direction of clinical anti-aging approaches and providing crucial scientific evidence against the effectiveness of young blood factors in aged organisms. ‘ said Pischel.

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