Sperm Donor’s TP53 Gene Raises International Concerns After Cancer Diagnoses in Children
A sperm donor, responsible for the conception of at least 67 children across several European countries between 2008 adn 2015, is believed to be a carrier of the TP53 gene, a gene linked to increased cancer risk. Disturbingly, cancer has already been diagnosed in 10 of these children, prompting calls for stricter international regulations on donor limits.
The Discovery
The issue came to light after two families, independently of each other, contacted a fertility clinic following cancer diagnoses in their children. Genetic testing revealed a shared, rare genetic variant linked to the donor.
Did you know? The TP53 gene, ofen referred to as the “guardian of the genome,” plays a critical role in preventing cancer by regulating cell division and preventing the growth of tumors. Mutations in this gene can considerably increase cancer risk.
The Genetic Link
Further inquiry by a lab revealed that the gene mutation coudl be linked to Li-Fraumeni Syndrome (LFS). LFS is a hereditary condition that predisposes individuals to a variety of cancers.Research across multiple children’s hospitals in Europe confirmed the presence of the variant in 23 children, with 10 already diagnosed with cancer, including leukemia.
Individuals with LFS are typically advised to maintain a healthy lifestyle and undergo annual MRI scans of the entire body for early detection.
European Sperm Bank’s Response
The European Sperm Bank confirmed the presence of the TP53 gene in some samples from the donor. However, they stated that at the time of the donations in 2008, the link between the gene and cancer was not yet well-established, and standard screening techniques did not detect it. Furthermore, the donor was reportedly in good health at the time of donation.
The European Sperm Bank, which currently enforces a limit of 75 families per donor, stated that the clinics they collaborate with have been notified.
Call for International Regulations
The situation has reignited discussions about the need for international regulations regarding the number of children conceived from a single donor. Experts argue that the case highlights the potential risks associated with widespread sperm donation,particularly when serious medical conditions are later identified in the donor.
This is an abnormal distribution of genetic diseases. Not every man has 75 children throughout Europe.
Dr. Edwige kasper, Biologist, University hospital of rouen
Dr. Kasper argued for a cross-border limit to mitigate such risks.
Pro Tip: Genetic counseling is highly recommended for individuals considering using donor sperm or eggs. This can definitely help assess potential risks and make informed decisions.
