JAKARTA – Some patients infected with the corona virus (Covid-19) have no symptoms or people without symptoms (OTG). Why is that?
Quoted from detikhealt, research conducted by a team at the University of Arizona, United States, found that SARS-CoV-2, the cause of Covid-19, can affect certain cells in the body, thereby relieving pain and making patients show no symptoms.
However, even if patients show no symptoms, they can still spread the virus.
Dr Rajesh Khanna, a professor at the Tucson School of Pharmacology Department of Medicine, said some Covid-19 patients are asymptomatic because the virus can cause suppression of pain, especially in its early stages.
This makes the patient feel that he has not experienced any changes in his vital organs. However, they can unconsciously transmit Covid-19 infection to many people, especially in the early days of infection.
“It makes perfect sense to me that the spread of Covid-19 occurs at an early stage, when you feel fine even though you are infected with the virus,” said Dr Khanna, quoted by the Times of India, Saturday (10/10 / 2020).
The US Centers for Disease Control and Prevention (CDC) indicates that transmission occurs mostly when symptoms do not appear in Covid-19 patients. The percentage risk of transmission is large, about 40 percent, and occurs early in the infection before symptoms appear or the asymptomatic phase.
But, why can’t Covid-19 patients feel sick? One reason that’s being studied is the way the coronavirus spike protein interacts with pain receptor cells in the body, reducing the chances of feeling sick.
Previously, the corona virus was known to enter the body by attaching to the ACE 2 receptor. However, scientists recently discovered that there is another way, namely with the help of neuropilin-1 receptor cells.
These proteins and cell-related receptor pathways are involved in processing and pain relief. When the Corona virus attaches to cells, it limits the function of vascular endothelial growth factor-A (VEGF-A), which is involved in nerve function and pain receptors and leaves people asymptomatic. ***