Here’s a breakdown of the information provided, focusing on Seek Labs‘ work and its implications:
Seek Labs’ Core Mission and Technology:
Goal: To develop programmable “seek-and-destroy” therapeutics and point-of-care molecular diagnostics to rapidly respond to health threats.
Platform: A layered architecture:
BioSeeker™ (Intelligence Layer): Continuously maps conserved viral vulnerabilities in real-time.
Deployment Layers:
PTAP™ (Programmable Target Ablation Platform): For programmable therapeutics.
seekit™: for molecular diagnostics.
Approach: Full-stack progress engine designed to accelerate response, innovation, and impact.
Location: Headquartered in Salt Lake City, Utah, and a member of biohive.
seek Labs’ Focus on Veterinary Pathogens:
Seek Labs is leveraging its platform to address significant threats in animal health, highlighting the interconnectedness of human and animal health (One Health).
African Swine Fever Virus (ASFV):
Problem: A major crisis causing over $100 billion in global economic losses and disrupting pork production.
Seek Labs’ solution: Developed an ASFV therapeutic candidate. Key Achievement: Successfully completed in vivo trials,increasing survival from 0% to nearly 60% in animals challenged with lethal doses of the pandemic strain.
Significance: First accomplished study in a veterinary model using a programmable therapeutic against a high-result foreign animal disease, demonstrating platform adaptability for other viral threats.
Capripox Viruses (Lumpy Skin Disease, Sheep and Goat Pox):
Problem: Cause widespread livestock outbreaks with over $1 billion in global losses due to culling, trade bans, and production declines.
Seek Labs’ Solution: Identified targets supporting a potential pan-Capripox therapeutic.
Reasoning: These viruses are closely related and share conserved genomic regions.
Classical Swine Fever (CSFV):
Problem: A persistent, highly contagious threat causing over $5 billion in global economic losses through trade restrictions, culling, and eradication campaigns.
Seek Labs’ Role: Demonstrates their capacity to develop programmable solutions for diverse, high-consequence threats with PTAP.
Broader Implications and Partnership Strategy:
Cross-Species Capability: Seek Labs’ work on these veterinary targets shows their ability to develop solutions for different species, strengthening global bio-surveillance and control.
Holistic Global Health Solution: By including veterinary pathogens,Seek Labs emphasizes the interdependence of human and animal health.
Partnering: Seek Labs is actively seeking qualified partners to:
Advance next-generation veterinary therapeutics. Improve health outcomes worldwide. Strengthen food security infrastructure.
Address a growing market need.
Partner Benefits: Access to a repository of mapped genomic targets and a precision mapping capability combined with their PTAP platform.
forward-Looking Statements and Disclaimer:
The press release contains forward-looking statements about Seek Labs’ technologies and plans.
These statements are subject to risks and uncertainties.
* The described technologies are investigational and have not been reviewed or approved by regulatory authorities like the FDA.
In essence, Seek Labs is positioning itself as a leader in developing rapid, adaptable therapeutic solutions for critical global health threats, starting with significant animal diseases that have major economic and food security implications. Their programmable platform,BioSeeker and PTAP,is highlighted as a key differentiator,enabling them to tackle diverse and high-consequence pathogens. They are actively seeking partnerships to bring these solutions to market.
