https://mundo.sputniknews.com/20210416/los-cientificos-logran-cultivar-embriones-mitad-humanos-mitad-monos-1111256797.html
Scientists manage to grow half-human, half-monkey embryos
Scientists manage to grow half-human, half-monkey embryos
As part of their study, the researchers used oocytes – the immature precursors of ovules – from female crab-eating macaques (Macaca
2021-04-16T15:57+0000
2021-04-16T15:57+0000
2021-04-16T16:14+0000
science
embryology
embryo
monkeys
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As part of their study, the researchers used oocytes – the immature precursors of eggs – from female crab-eating macaques (Macaca fascicularis), which matured and then fertilized with sperm of the same species. These cells, after six days, divided and transformed into blastocysts. In a normal pregnancy, the blastocyst would implant in the uterus and then give rise to an embryo, but as part of the experiment, they were put on laboratory plates. In addition, they underwent a treatment that allows the monkey embryos to survive for up to 20 days outside the maternal body. Six days after the cells were fertilized, 25 human stem cells were injected into each of the blastocysts. A day later, all 132 embryos still contained human cells, but only 111 embryos successfully adhered to laboratory plates, analogously to what they would in the mother’s womb. On the ninth day of the experiment, more than half of the surviving embryos still contained human cells. About a third of them still contained human cells on day 13. The number of human cells that survived as part of the experiment far exceeded that seen in a previous study, human cells were injected into pig embryos. The research hope that, in the future, chimeric mono-human embryos can serve as models for the study of human disease, embryonic development and aging. By looking closely at the interaction of cells of different origins in embryos, Scientists could also discover ways to help human cells survive among animals, potentially a breakthrough in methods for growing human organs in living animal models. Research like this could open a window into human biology that otherwise, it would require experimentation in humans, which is currently impossible. However, the development of chimeric organisms containing cells from two or more species raises its own ethical concerns, Live Science stressed, the study published April 15 in the scientific journal Cell.
https://mundo.sputniknews.com/20210318/crean-el-primer-modelo-del-embrion-humano-a-partir-de-celulas-de-la-piel–1110146146.html
https://mundo.sputniknews.com/20200412/usan-rayos-x-para-estudiar-embriones-de-dinosaurios–1091087546.html
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embryology, embryo, monkeys
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Scientists have succeeded in injecting dozens of human stem cells into monkey embryos. The hybrids obtained in the experiment survived up to almost three weeks in laboratory dishes.
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As part of their study, the researchers used oocytes – the immature precursors of eggs – from female crab-eating macaques (Macaca fascicularis), which matured and then fertilized with sperm of the same species. These cells, after six days, divided and transformed into blastocysts.
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In a normal pregnancy, the blastocyst would implant in the uterus and then give rise to an embryo, but as part of the experiment, they were put on laboratory plates. In addition, they underwent a treatment that allows the monkey embryos to survive up to 20 days outside the maternal body.
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Six days later after fertilization, the cells were injected into each of the blastocysts 25 human stem cells. A day later, all 132 embryos still contained human cells, but only 111 embryos successfully adhered to laboratory plates, analogous to how they would in the maternal uterus.
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On the ninth day of the experiment, more than half of the surviving embryos still contained human cells. About a third of them still contained human cells on day 13.
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The number of human cells that survived as part of the experiment far exceeded that observed in a previous study, human cells were injected into pig embryos.
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The authors of the research hope that, in the future, chimeric embryos mono-human can serve as models for the study of human disease, embryonic development, and aging.
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April 12, 2020, 17:38 GMT
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By looking closely at the interplay of cells of different origins in embryos, scientists could also discover ways to help human cells survive among animals, potentially a breakthrough in methods for growing human organs in live animal models.
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Research like this could open a window into human biology that would otherwise require experimentation in humans, which is currently impossible. However, the development of chimeric organisms that contain cells of two or more species raises your own ethical concerns, subrayó live Science.
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