In order for Leishmania to live, it is critically important for him to have the protein centrin, in the absence of which the parasite instantly becomes weaker, and its structure is deformed, it says on the university website. In the end, using the CRISPR tool, the scientists identified and removed two separate genes that were responsible for the production of centrin in the pest’s body. It was this step that helped to “neutralize” Leishmania major, while leaving the parasite as an excellent target for the human immune system, which trained on it to fight the full-fledged and dangerous representatives of this organism.
Experts said that a new method of converting a parasite into a drug has been successfully tested on animals. The next step is to test it on a person.