Experts from the Fiocruz Development Center analyzed Atazanavir, a drug used against HIV that could be effective against coronavirus.
A group of Brazilian scientists from the Fiocruz center may have found a drug against the coronavirus. This is Atazanavir, a remedy used to treat HIV-infected patients.
This medicine has an anti-inflammatory function, since it helps to reduce the inflammatory process in the lungs. According to recent research, the drug may inhibit viral replication of SARS-CoV-2.
Recall that this center is located in Brazil and is currently one of the largest medical research centers in Latin America, working directly with the government of that country.
Coronavirus and Brazil
As a result of the investigations and follow-up that has been done to the virus, the experts noticed several characteristics. One of the first is that Atazanavir is able to stop the multiplication of the coronavirus in the body.
This would be achieved thanks to its anti-inflammatory capacity, which is why it is used to face AIDS.
As Atazanavir was exposed to the SARS-CoV-2 spike protein, it showed a positive reaction. According to a statement delivered by the Institution, the drug managed to “reduce the proteins that are linked to the inflammatory process in the lungs.”
The direct intervention of the drug can affect the reduction of the serious clinical picture generated by the coronavirus. Although the investigation is still preliminary, it may be a door for a possible drug to face the pandemic.
In the words of Thiago Moreno, Fiocruz researcher and one of the project coordinators, “Testing for drugs already approved for other uses is the fastest strategy that science can offer to combat COVID-19.”. For his part, the expert also emphasized that social distancing is also another essential measure.
For their part, experts will continue studies to analyze the long-term effectiveness of the drug. It is hoped that the utility may increase with the combined use of Ritonavir and Atazanavir, which are targeted medicines to treat AIDS.
Possible medication for the disease
Researchers at the Center for Technological Development in Health believe they have found a more effective mediation than Chloroquine. According to them, Atazanavir causes better bioavailability in the respiratory tract. This situation can be transcendental in the fight against SARS-CoV-2 and its reproduction.
This means that the drug manages to occupy the cleft of the active substrate during molecular analyzes. With this, it could block the advance of the virus.
The researchers will continue to test the reaction through various cell types using in vitro assays. Those that will be dealt with will be the following:
- Lung cell
- Human epithelial cell
- Human primary monocytes