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Safety Profile and Influence Factors of Incadronate Disodium Treatment

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Okay,I’ve ​analyzed the provided⁣ text. It appears to be a ⁢snippet from a medical research paper discussing the ⁢use of bisphosphonates in cancer ‍treatment, specifically focusing on their side effects. ‌The text is‌ heavily corrupted‌ with repeated phrases and “citations” that are clearly artifacts of a text extraction process.‍ I’ll provide a summary of the key information, ignoring⁢ the noise, and then point out the issues with the text.

Summary of Key Information (Cleaned):

The study​ investigates the adverse⁢ effects of bisphosphonates (specifically, it mentions “bisphosphonates” and “zoledronic acid“) in patients ⁣with cancer, notably those with bone metastases.

Dental Issues: Bisphosphonates were associated with an ‍increased likelihood of dental issues. Table 2 details characteristics of‌ patients with and⁣ without these ⁢issues.
Acute Phase Reactions: ‌These reactions (flu-like ‌symptoms) ‌were observed in ⁣26.2% of‍ patients. ​ ⁤Factors associated with⁤ these⁤ reactions included:
Higher doses (10mg vs. 5mg)
Multiple metastatic sites
⁤ Lower hemoglobin⁤ levels
‌ ⁢⁤
Bone ⁤and other site of metastases were considered at higher risk.
⁤ ⁤ Table⁢ 4 and ‌5 provide details on these reactions. Other Adverse Effects:
‍ Renal dysfunction occurred in⁣ one patient (creatinine increased from 0.63mg/dL to 1.17mg/dL).
Decreased calcium levels (<2mmol/L) were observed in⁢ 4.7% of patients, causing numbness and cramps. ⁢ ⁣ The study‍ did not observe atrial fibrillation or conjunctivitis.

Problems with the text:

The text is riddled with errors,‍ likely ⁤caused by ​a flawed Optical Character Recognition (OCR)‌ or text‍ extraction process. here’s a breakdown of the issues:

Repetitive citations: The text constantly inserts phrases like “[number]“,⁣ ““, and “href” followed‌ by numbers. These are‍ remnants of HTML tags or citation markers​ that haven’t been ⁢properly processed.
Fragmented Sentences: Sentences⁤ are‌ broken up and interspersed with these citation⁢ markers,‍ making them arduous to read.
Word Corruption: Words are sometimes partially replaced with citation-related text (e.g., “patients” becomes “patients[number]“). Table References: References to tables ⁣are also corrupted ​with similar tags.
Inconsistent Formatting: The formatting is erratic, with inconsistent use of bolding and line‍ breaks.
Meaningless⁢ Phrases: Phrases like “clinical,” “the,” and “and” are ‍repeated in a way that ⁤doesn’t⁣ make sense in the context.

In essence, the text is a garbled version of a scientific paper. ‍It requires significant cleaning and correction to be usable.

If you provide ⁤more of the text, I can attempt‌ to extract ⁣more information, but the quality of the output will be limited by the extent ‌of the ⁢corruption. If you have access to the original document ⁤(PDF, Word⁣ file, etc.), that would be the best way to obtain‌ a clean version.

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