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risk of brain tumor because of drugs progestins

The risk of brain tumors – meningiomas – is confirmed for medication progestins used in the management of the menopause, menstrual disorders and endometriosis, alert the Agency of the drug (MSNA) on the basis of an extensive epidemiological study.

This new warning concerning the Lutéran acetate (chlormadinone) and the Lutényl acetate (nomégestrol), and their generics. “The risk increases with the high-dose and a treatment on a long-term“, points out Jean-Michel, Race director of the drug endocrinology and gynecology at the MAN. More than 400,000 women were taking this treatment in 2019.

The meningioma is a tumor of the envelopes of the brain, the large majority are benign.
Women treated for more than 6 months by these molecules (acetate nomégestrol or of chlormadinone) are exposed to a risk of developing this tumor multiplied by 3,3, and 3.4, respectively, compared with women not treated with these drugs, according to the study. The risk is multiplied by 12.5 to 5 years of treatment with the Lutényl and its generic and by 7, from 3.5 years for the Lutéran and its generic. Moreover, the risk of meningioma leading to intracranial surgery increases sharply with age: it is, for example, 3 times higher for women aged 35 to 44 years old than for those 25 to 34 years.

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