Research Finds Effectiveness of Weaker COVID-19 Vaccine in Obese People


Recent research in Turkey says obesity can reduce the effectiveness of the COVID-19 vaccine in people who have never been exposed to the Corona virus. So, how does the efficacy of the COVID-19 vaccine compare in people with excess weight versus people with normal weight? How much difference?

Based on results presented this week at the European Congress on Obesity in Maastricht, the Netherlands, the study was conducted on people who had never been infected with SARS-CoV-2 and had already received Pfizer and Sinovac’s COVID-19 vaccines.

In Pfizer users it was found that severely obese patients had antibodies more than three times lower than normal weight people.

Meanwhile, in Sinovac recipients who were severely obese and had never been exposed to COVID-19, antibody levels were 27 times lower than normal weight people.

In the study, researchers compared the immune response to the vaccine in 124 severely obese volunteers, with a body mass index of 40 and over, and 166 normal-weight volunteers with a body mass index of less than 25. Overall, 130 participants had received two doses of the vaccine. Pfizer/BioNTech mRNA and 160 have received two doses of Sinovac inactivated virus vaccine.

“(Pfizer/BioNTech vaccine) can produce significantly more antibodies than CoronaVac in severely obese people,” study leader Volkan Demirhan Yumuk of Istanbul University said in a statement.

“Further research is needed to determine whether higher levels of these antibodies confer greater protection against COVID-19.”

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