Patients experiencing motor symptoms on the right side of their body may face a more pronounced cognitive decline and a higher risk of dementia. Conversely, those with symptoms on the left side are more likely to develop psychiatric issues, including depression, anxiety, and difficulties with emotion recognition. These findings stem from a extensive review of 80 studies conducted by a team from the University of Geneva and the University Hospitals in Geneva. The review, published in npj Parkinson’s Disease, a Springer Nature group publication, examined the influence of the side of initial motor symptom appearance on non-motor symptom progression and treatment response in Parkinson’s disease.
While the analysis acknowledged variability across studies, it concluded that considering the asymmetry of motor symptoms in the diagnosis and treatment of Parkinson’s disease could substantially enhance personalized care. The research highlights that motor symptoms on the right side of the body are indicative of dysfunction in the left hemisphere of the brain, and vice versa for left-sided symptoms affecting the right hemisphere.
Dementia Biomarkers and Right-Sided Predominance
The swiss team’s analysis suggests that motor symptom asymmetry can help establish distinct patient phenotypes from the diagnostic stage, or even during the prodromal phase. Patients with predominantly right-sided motor symptoms often exhibit memory, executive function, and language disorders, likely due to left hemisphere damage. These individuals also appear more vulnerable to apathy. Some studies have identified dementia biomarkers, such as left hemisphere atrophy and specific blood test results, in these patients. In contrast, those with left-sided symptom predominance tend to experience more visuospatial and emotional deficits, potentially linked to right hemisphere damage.
Beyond disease progression, motor asymmetry may also influence responses to treatments like deep brain stimulation and dopaminergic agonists. The clinical benefits of brain stimulation,as a notable exmaple,seem highly dependent on the asymmetry of motor symptoms. Studies indicate that patients with left-sided predominance may be more susceptible to post-stimulation neuropsychological decline but show greater enhancement in psychiatric symptoms. Conversely, those with right-sided predominance might be less prone to cognitive side effects but more exposed to emotional symptoms.
This article provides general information and does not constitute medical,financial,or legal advice. Consult with qualified professionals for personalized guidance.
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