6,422 cases were registered on Friday, along with 28 deaths.
The record is set on the same day as the Cuban medical authorities approved the first of five self-produced vaccines.
About half of the new cases are in the province of Matanzas, where the tourist destination Varadero is located.
The infection has increased slowly but surely since Cuba reopened to tourism in November, which has probably contributed to the wave of infection the country is now experiencing.
A total of 219,000 cases of infection and 1,431 deaths have been registered since the start of the pandemic. But the country has escaped fairly well. In the whole of 2020, there were 12,200 cases of infection.
The new Abdala and Soberana 02 vaccines have already been tested on millions of people. According to the state vaccine company BioCubaFarma, the vaccines are over 90 percent effective.
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