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{
"@context": "https://schema.org",
"@type": "FAQPage",
"mainEntity":[
{
"@type": "Question",
"name": "What is the role of ZNF280A in DNA repair?",
"acceptedAnswer": {
"@type": "Answer",
"text": "ZNF280A is a chromatin factor that plays a crucial role in repairing DNA double-strand breaks (DSBs). It is indeed recruited to sites of DNA damage and facilitates the repair process."
}
},
{
"@type": "Question",
"name": "What is DNA double-strand break (DSB)?",
"acceptedAnswer": {
"@type": "Answer",
"text": "A DNA double-strand break (DSB) is a severe type of DNA lesion where both strands of the DNA molecule are broken. If unrepaired, DSBs can led to mutations, cell death, and various pathologies, including cancer."
}
},
{
"@type": "question",
"name": "What is 22q11.2 distal deletion syndrome?",
"acceptedAnswer": {
"@type": "Answer",
"text": "22q11.2 distal deletion syndrome is a human developmental syndrome characterized by the deletion of a specific region on chromosome 22. Patients wiht this syndrome frequently enough exhibit clinical features such as microcephaly, short stature, developmental delay, cognitive impairment, and immune deficiency."
}
},
{
"@type": "Question",
"name": "How does the absence of ZNF280A affect patients with 22q11.2 distal deletion syndrome?",
"acceptedAnswer": {
"@type": "Answer",
"text": "The absence of ZNF280A in patients with 22q11.2 distal deletion syndrome leads to increased DNA damage and defective DNA double-strand break repair. This contributes to the clinical features observed in these patients."
}
},
{
"@type": "Question",
"name": "What are chromatin factors?",
"acceptedAnswer": {
"@type": "Answer",
"text": "Chromatin factors are proteins that regulate gene expression by influencing the structure and organization of chromatin, the complex of DNA and proteins that make up chromosomes."
}
},
{
"@type": "Question",
"name": "Why is identifying chromatin factors in DNA repair challenging?",
"acceptedAnswer": {
"@type": "Answer",
"text": "Identifying chromatin factors in DNA repair has been challenging due to the lack of high-
