Lionel Messi celebrates the goal against Napoli in the 2019-2020 Champions League last 16 second leg match at the Camp Nou Stadium.
Unlike previous years, the last eight phase matches will use system one leg due to the COVID-19 pandemic.
Bayern qualified for the quarter-finals after winning 7-1 on aggregate over Chelsea in the last 16.
Barcelona advanced to the last eight after winning 4-2 on aggregate over Napoli in the last 16 phase.
This quarter-final match will be the meeting of Lewandowski and Messi as the two mainstay players from the two clubs.
The last meeting of the two in the Champions League occurred during the 2014-2015 season in the semifinals.
On the match leg first at the Camp Nou, Messi led Barcelona to win by scoring two goals plus one assist.