Lavender and coriander oil effective against neurotoxic Alzheimer’s proteins – naturopathy & naturopathic specialist portal

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Given the suspected link between beta-amyloid deposits in the brain and Alzheimer For years, researchers have been looking for ways to prevent these deposits. The Italian research team led by Vincenzo De Feo from the University of Salerno pursued a different approach in their current study and examined whether the cells can be protected against the neurotoxic effects of beta amyloid with lavender and coriander oil. Their results were published in the specialist magazine “Phytotherapy Research“.

Looking for natural ingredients

“With no cure or preventive therapy currently available to counter Alzheimer’s disease, we investigated compounds of natural origin to find new potential neuroprotective agents for treatment,” the research team explains.

Neuroprotective effects of essential oils examined

In experiments on cell cultures with so-called “neuronally differentiated PC12 cells”, the researchers tested the neuroprotective effect of essential oils from lavender and coriander and their main active ingredient linalool against the neurotoxicity caused by certain beta-amyloid oligomers (Aβ1‐42 oligomers) . These oligomers are considered to be key molecular factors in neurodegeneration in Alzheimer’s disease, according to the research team.

Improved cell viability

“We found that essential oils made from lavender and coriander at the concentration of 10 μg / mL and linalool at the same concentration were able to improve cell viability and reduce nuclear morphological abnormalities in cells that lasted for 24 hours were exposed to the Aβ1-42 oligomers, ”report the researchers.

The result on the neuronally differentiated PC12 cells also agrees with previous in vivo studies in which a possible neuroprotective potential of the essential oil from lavender and coriander was reported, the research team added.

The current study also showed that lavender and coriander oil as well as linalool “counteract the increase in the intracellular production of reactive oxygen species induced by Aβ1-42 oligomers and the activation of the pro-apoptotic enzyme caspase-3.”

Review therapeutic uses

According to the research team, the current study provides important evidence that the essential oils from lavender and coriander, as well as their main component linalool, could be used as natural active ingredients against the neurotoxicity of beta-amyloid. Further studies should now examine the possible uses in humans and the effect on the course of Alzheimer’s disease. (fp)