Gene linked to Increased Melanoma Risk Concentrated in Katwijk Population
Research led by dermatologist Remco van Doorn of the Leiden University Medical Center has identified a gene substantially increasing the risk of melanoma, with a notably higher concentration of carriers within the population of Katwijk, Netherlands. Van Doorn attributes this concentration to the townS relatively “stable” population – meaning multiple generations remain in the area, facilitating the gene’s persistence.
while the gene isn’t exclusive to Katwijk and exists in other countries, its prevalence is substantially higher within the community.Van Doorn estimates “a few hundred” residents carry the gene, though the actual number may be greater.Importantly, carrying the gene does not guarantee the development of melanoma, but significantly elevates the risk.
The municipality of Katwijk has been informed to raise awareness of the gene’s presence among residents. Though, widespread medical check-ups are not recommended. Individuals with a family history of melanoma – specifically, having one or two immediate family members diagnosed with the disease – are advised to consult with their doctor for screening.
Van Doorn highlights a concerning correlation: carriers of this gene also face a “slightly increased” risk of developing pancreatic cancer.
Early detection is crucial for those who carry the gene. Individuals identified as carriers are recommended to undergo skin examinations twice a year. This allows for early detection and removal of melanoma, significantly improving prognosis.Delaying detection allows the disease to progress, potentially reaching a stage where treatment options are limited, often requiring immunotherapy with a reduced chance of a cure.
Van Doorn clarifies that this gene is unrelated to “Katwijk disease,” a separate genetic predisposition causing brain hemorrhages.He emphasizes that “Katwijk disease” isn’t a disease itself, but rather a gene increasing the risk of developing the condition.
Skin cancer, including melanoma, is the most common form of cancer in the Netherlands.[[[[(Article includes a link to a video explaining how to recognize skin cancer)]
