The Science Behind PP405

The PP405 molecule targets a protein within the stem cells of hair follicles, which is responsible for maintaining their dormant state. By inhibiting this protein, the stem cells are stimulated to “wake up” and initiate hair growth. This advancement is the culmination of nearly a decade of laboratory research.

According to UCLA scientists, PP405 is a conveyor molecule able to stimulate full hair growth.

Early Trial Results Show Promise

Initial human trials conducted in Orange County have been very encouraging, according to William Lowry, a professor of molecular, cellular, and developmental biology at UCLA and one of the study’s authors.In 2023, researchers observed that a topical night request of PP405 for just one week produced a statistically meaningful impact.

Lowry cautioned that no product will work for all people, but stressed that new tests with more participants are underway.

A Potential Game-Changer

Researchers believe that this treatment could lead to real hair growth, unlike many other products that only produce slight fluff. The team, comprised of William Lowry, Heather Christofk (associate professor of biological chemistry), and Michael Jung (professor of chemistry), is optimistic about the potential of this treatment to reverse common hair loss, which affects over 50% of men and 25% of women before the age of 50.

Lowry admitted initial concerns that PP405 might damage follicles,but they were surprised to find that it did not.

Pelage Pharmaceuticals: A New Hope

Through the UCLA technology transfer group, the researchers founded Pelage Pharmaceuticals, a company dedicated to medical development. Pelage’s platform targets a novel mechanism to activate stem cells and regrow hair, based on the finding that hair follicle stem cells have a unique metabolic switch [[2]]. Pelage’s treatment has the potential to induce robust hair growth for all genders, skin types, and hair types and is non-invasive [[2]].

According to UCLA researchers, they have discovered a new way to activate the stem cells in hair follicles that are responsible for hair growth [[3]].

FDA’s approvals usually take, but we believe that it will be worth waiting.

William Lowry, professor, UCLA

the Quest for a cure

The search for a baldness cure is an age-old pursuit. Despite advancements, few treatments have proven effective for more than one in three people, leading many to explore unproven therapies or costly surgeries.

At some point, most people – both men and women – experience hair loss… and this usually affects its psychological well-being, explained Lowry.

FAQ About PP405 and Hair Loss

What is PP405?

PP405 is a molecule discovered by UCLA scientists that stimulates hair growth by activating dormant hair follicles.

How does PP405 work?

It inhibits a protein in hair follicle stem cells,causing them to “wake up” and initiate hair growth.

Are there any human trials?

Yes,early human trials have shown promising results with topical night application.

When will it be available?

The approval process takes time,but researchers believe it will be worth the wait.

Who is behind this research?

The research is led by William Lowry, Heather Christofk, and Michael Jung at UCLA.