Suara.com – Some time ago, a recent study revealed nearly 80 percent of people were infected Covid-19 have no symptoms.
The author suspects that the reason for the spread of Covid-19 is because in the early stages of the disease, sufferers feel fine as if they have not had the virus.
“This research raises that possibility pain“As an early symptom of Covid-19, it can be reduced by the SARS-CoV-2 protein surge because the virus blocks the body’s pain signal pathways,” said Rajesh Khanna, Ph.D., professor in the Department of Pharmacology at the University of Arizona School of Medicine, Tucson.
Most medical experts think SARS-CoV-2 infects when the viral protein spike protein attaches to the ACE2 receptor on human cells.
In fact, the virus can also use a second receptor, neuropilin-1, to enter the human body.
Khanna explains that many biological pathways signal the body to feel pain. One of them is through a protein called vascular endothelial growth factor-A (VEGF-A).
These proteins play a vital role in blood vessel growth, but have also been linked to diseases such as cancer, rheumatoid arthritis and, most recently, Covid-19.
“Like a lock in a padlock, when VEGF-A binds to neuropilin receptors, they initiate a series of events that result in neuronal hyperexcitability, leading to pain.” he continued.