“The age to predict breast cancer with a simple blood test is imminent”
Research has shown that changes in blood proteins are evident long before breast cancer is diagnosed.
A research team from Leiden University Medical School in the Netherlands has revealed that breast cancer patients experience changes in the levels of six proteins in their blood up to two years ago. The study’s lead author, Assistant Professor Vilma Musker (surgeon) at Leiden University Medical School in the Netherlands, said: ‘Increases or decreases in protein levels may predict breast cancer from 1 to 2 years before onset”. Based on the results of this study, it is expected that it will be possible to develop a blood test method that predicts breast cancer up to two years earlier.
In 2011, the research team initiated “TESTBREAST”, a clinical trial for early serum screening of breast cancer. 1174 women at high risk of breast cancer due to a family history or genetic mutation participated. They were tested in one of nine Dutch hospitals and provided blood samples at least once a year. All of the women diagnosed with breast cancer also provided blood samples.
The research team analyzed 30 blood samples from three women without breast cancer and three women diagnosed with breast cancer. As a result, women diagnosed with breast cancer were found to have had changes, such as higher or lower levels of six proteins in their blood, up to two years ago.
Professor Musker said: ‘If we develop a blood test method using this study, it will be safe, convenient and cost much less.’
According to the research team, more than 2.3 million women worldwide have been diagnosed with breast cancer. It is estimated that by 2040, there will be 3 million new cases annually and over 1 million deaths from breast cancer each year.
Early detection of breast cancer can significantly increase the patient’s survival rate. According to the American Cancer Society (ACS), patients with localized breast cancer whose cancer cells have not spread to other areas have a 99 percent chance of surviving five years or more after diagnosis.
The results of this study (Longitudinal Serum Protein Analysis of Women with a High Risk of Developing Breast Cancer Reveals Large Interpatient Versus Small Intrapatient Variations: First Results from the TESTBREAST Study) were published in the International Journal of Molecular Sciences and published in the UK . Introduction of “Medical News Today” in health media.