tiny signaling molecules released by fat cells may accelerate teh progress of amyloid plaques, a hallmark of Alzheimer’s disease, according to a new study published October 2, 2025. Researchers discovered a link between obesity adn increased plaque buildup in the brain, suggesting a potential pathway through which excess weight contributes to neurodegenerative disease.
The findings, released today, October 2, 2025, carry significant implications for the growing number of individuals affected by both obesity and Alzheimer’s. With rates of both conditions rising globally, understanding the biological connections between them is crucial for developing preventative strategies and potential treatments. The study highlights a previously underappreciated mechanism by which metabolic dysfunction can directly impact brain health, perhaps opening new avenues for intervention.
The research team identified specific extracellular vesicles-nanoscale packages secreted by cells-released from adipose tissue in obese individuals. These vesicles contain microRNAs that,when taken up by brain cells,promote the production of beta-amyloid,the protein that aggregates to form plaques. Experiments demonstrated that these vesicles accelerate plaque formation in laboratory models.
“We found that these tiny messengers from fat cells can directly influence the pathology of alzheimer’s disease,” explained a researcher involved in the study.”This suggests that addressing obesity and metabolic health coudl be a vital component in reducing the risk of developing Alzheimer’s.”
The study was conducted using both in vitro and in vivo models, providing robust evidence for the connection. Further research is planned to investigate the specific microRNAs involved and to explore potential therapeutic targets for disrupting this pathway. The findings underscore the importance of maintaining a healthy weight and lifestyle for long-term brain health.
