The fight againstAlzheimer it can be enriched with a new hope and a new weapon to help counter the progression of the disease. The credit goes to a team of researchers from the Pablo de Olavide University and the results obtained are closely related to the discovery that steroid hormones, the same ones that regulate processes such as changes associated with puberty, influence the development ofAlzheimer.
This discovery led to the identification of a drug for the treatment of this neurodegenerative disease of the central nervous system, STX64.
The results of the study, described in detail on the pages of the specialized journal Nature Communications, pave the way for the development of a new treatment for Alzheimer’s.
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The worm study
deepening
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In an initial test conducted on worms, Caenorhabditis elegans, which induced the disease of Alzheimer, the research team found that some steroid hormones modified with the addition of a sulfate group improved the symptoms of this disease. By treating animals with STX64, an oral drug that inhibits sulfatase activity, the researchers noted an improvement in the disease.
The same result also emerged from a subsequent test conducted on mice induced with Alzheimer’s disease. “These animals, which are characterized by loss of cognitive ability with age, when they were treated with Stx64 and recovered memory to the same level as healthy mice,” the authors specify in a note published in university website. The research group has obtained a European patent on the STX64 compound, owned by the Pablo de Olavide University, and will carry out a clinical trial on Alzheimer’s patients lasting one year. “We are not alone faced with the discovery of a new mechanism that could participate in regulating the appearance ofAlzheimer, but also against a possible treatment that could be used in humans, “explained Manuel J. Muñoz, coordinator of the research team.
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