Executive Order on Unlocking Cures for Pediatric Cancer Through Artificial Intelligence
Executive Order of September 30, 2025
By the President of the United States of America
A Proclamation
Pediatric cancer remains a devastating disease, demanding urgent and innovative action. Advances in artificial intelligence (AI) present a meaningful possibility to accelerate research, improve treatment, and ultimately unlock cures for children battling cancer. this order directs focused efforts to harness the power of AI to combat pediatric cancer, while upholding patient privacy and ensuring responsible data practices.
Sec.1. Utilizing Artificial Intelligence to Accelerate Pediatric cancer Research
The secretary of Health and Human Services, in coordination with the Advancing Pediatric Survivorship and Treatment (APST) initiative, shall led efforts to integrate AI into pediatric cancer research. This includes:
(a) Prioritizing the submission of AI to improve the speed and efficiency of drug finding and development, enhance patient-ready analysis, and utilize AI to better select participants for clinical trials.
(b) Enhancing data analysis of complex biologic systems with AI tools to radically improve predictive modeling of patient response, disease progression, and treatment toxicity. This will focus on transforming multi-omics data and imaging data into novel diagnostic,prognostic,and therapeutic biomarkers.
(c) Improving clinical trial design,access,and outcomes for patients by incorporating multimodal data and using AI approaches to maximize the utilization of data from clinical trials and improve accessibility,recruitment,governance,conduct,and interpretation of clinical trial results.
Sec. 2. Increasing investment and Engagement in Pediatric cancer Research and Care infrastructure
The Maximizing AmericaS Health and Advancement (MAHA) Commission, in coordination with the Secretary of Health and Human Services, the Director of the Office of Management and Budget, the Director of the National Institutes of Health, and the APST, shall prioritize expanding pediatric cancer research and advancements in care. This will be achieved by identifying and implementing strategies for:
(a) Increasing investment from existing federal funds for the Childhood Cancer Data Initiative (CCDI) and other Federal Government initiatives that address pediatric cancer.
(b) Encouraging the private sector to leverage the most advanced technologies, including those based on AI, to the maximum possible extent in the pursuit of cures for pediatric cancer.
Sec. 3. Improving Data sharing and Empowering Patients
the Secretary of Health and Human Services, in consultation with the APST, shall work to ensure that AI innovation is appropriately integrated into current work on interoperability. This will maximize the potential for electronic health record and claims data to inform private sector and academic research and clinical trial design, while ensuring that patients and parents maintain control over their health information. Moreover, the Secretary shall work to finalize interoperability standards for patient data used with AI, accounting for both structured and unstructured data and enabling safe and privacy-compliant data exchanges.
Sec. 4. Definition
For the purposes of this order, the term “artificial intelligence” or “AI” shall have the meaning set forth in 15 U.S.C. 9401(3).
Sec. 5.General Provisions
(a) Nothing in this order shall be construed to impair or otherwise affect the authority granted by law to an executive department or agency, or the head thereof, or the functions of the Director of the Office of Management and Budget relating to budgetary, administrative, or legislative proposals.
(b) This order shall be implemented consistent with applicable law and subject to the availability of appropriations.
(c) This order is not intended to,and does not,create any right or benefit,substantive or procedural,enforceable at law or in equity by any party against the United States,its departments,agencies,or entities,its officers,employees,or agents,or any other person.
(d) The costs for publication of this order shall be borne by the Department of Health and Human Services.
DONALD J. TRUMP
THE WHITE HOUSE,
September 30, 2025.
