a group of experts takes stock

Oxidative stress, disruption of circadian rhythms, increased inflammation are all factors that promote cardiovascular disease. A group of German researchers reports on the relationship between the environment and these biological disturbances.

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With nearly 400 deaths per day in France, the diseases cardiovascular regrouping themyocardial infarction, stroke, peripheral and hypertensive vascular diseases are the second leading cause of death, according to Public Health France. The study of risk factors individual non-modifiable (heredity, sex, age) or modifiable (tobacco, diet, sedentary lifestyle) is widely done. In France, there is a system for monitoring the causes of cardiovascular disease.
Cardiovascular diseases are favored by:

smoking; obesity; bad … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/3/e/8/3e8c10597a_84444_coeur.jpg “data-url = “https://www.futura-sciences.com/sante/definitions/coeur-maladie-cardiovasulaire-15398/” data-more = “Read more”>cardiovascular illnesses and numerous preventive actions promoting smoking cessation, respect for hygienic-dietetic rules and the practice of an activity The theories established by physics apply within well-defined frameworks.
La physique…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/8/9/6/896f032c90_91933_physique-def.jpg” data-url=”https://www.futura-sciences.com/sciences/definitions/physique-physique-15839/” data-more=”Lire la suite”>physique.

Because the study of the impact of the environment on health requires a multidisciplinary approach, involving different complex levels of In the space field, a star sensor is an optoelectronic device used for the orientation of satellites. “Data- image = “https://cdn.futura-sciences.com/buildsv6/images/midioriginal/6/3/4/6349c4ee96_50036247_capteurrecopesca-image-node-full.jpg” data-url = “https: //www.futura- sciences.com/tech/definitions/technologie-senseur-8460/ “data-more =” Read the definition “>sensors and techniques (metadata processing, bioinformatics, systems biology), environmental risk factors are difficult to identify. Moreover, the management of these risks would imply a community intervention which is difficult to deploy. Thanks to a meta-analysis, a group of German experts recently took stock on studies dealing with environmental factors such as noise, air pollution, light pollution and their contribution to the development of cardiovascular illnesses.

A multidisciplinary approach: the concept of exposome

The emerging notion of exposome allows the study of the lifetime effects of all environmental exposures on biochemical pathways and more generally, on health. This approach, which can only be multidisciplinary, integrates an individual’s exposome as a whole made up of the natural, personal and social environment strongly linked to the biochemical changes that can affect their health. The latter such as the modification of Genoa of the’circadian clock, the liberation ofstress hormones (cortisol), the production of Species is the fundamental entity of classifications, which brings together living beings with a set of morphological and anatomical characteristics, … “data-url =” https: //www.futura-sciences. com / planete / definitions / zoologie-espece-2261 / “data-more =” Read more “>cash reactive oxygen cause damage to cells and organs that can induce or promote various pathologies.

Noise, air pollution and light pollution

In France, 7 million people live in places of high noise exposure (beyond the threshold of 65 dB) and the increase in noise is associated with an increase in There are several types of … “data-image =” https://cdn.futura-sciences.com/buildsv6 /images/midioriginal/4/5/7/4575b9b026_53969_prevalence.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/medecine-prevalence-2818/ “data-more =” Read the continued “>prevalence and the incidence of They can be developed before birth (we speak of congenital heart disease) or acquired in adulthood (coronary heart disease). “data-image =” https://cdn.futura-sciences.com/ buildsv6 / images / midioriginal / d / 6/2 / d62e87de76_50035264_coeur-wikimedia.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/medecine-cardiopathie-6386/ “data-more = “Read the definition”>cardiopathies ischemic (the heart is not getting enough O2). Indeed, the noise by disturbing the sleep rhythms generates the production of peptide, lipid and steroid hormones
Hormones are used to transmit a chemical signal: they exert an action at … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/f/8/b/f8bca49d5d_98004_ths-hormone -menopause.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/medecine-hormone-751/ “data-more =” Read more “>hormones of stress (cortisol and catecholamines), affects catabolism: it extracts energy from nutrients, by degradation of energy molecules (carbohydrates, lipids …) … “data-image =” https: // cdn. futura-sciences.com/buildsv6/images/midioriginal/b/6/3/b63b38ae32_50034242_marathon-sport-addiction-cc.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/biologie -metabolism-781 / “data-more =” Read more “>metabolism (increase in blood sugar and The roles of cholesterol
It is part of the composition of cell membranes and stabilizes them.In the human body, cholesterol is the precursor of steroid hormones … “data-image =” https://cdn.futura-sciences.com/buildsv6/images /midioriginal/8/d/9/8d9af925e3_50034229_cholesterol-dr-02.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/medecine-cholesterol-687/ “data-more =” Read more “>cholesterol), increases the activity of the amygdala (producing coronary inflammation). Moreover, the excess sound brings about epigenetic changes in theADN leading to severe inflammation and atherosclerosis subclinique.

On the other hand, the studies cited underline the association of pollution fromair and cardiovascular disease. One of them shows a reduction in cardiovascular events in China and Europe during confinement linked to pandemic Covid-19. It would seem that exposure to Given the small dimensions of these particles, they cannot sediment under the action … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal /7/d/d/7dda41bfd5_50035418_analyse-qualite-air-pollution-particule-brewbooks-ccby-2.jpg “data-url =” https://www.futura-sciences.com/planete/definitions/developpement-durable- fine-particle-6723 / “data-more =” Read more “>fine particles (PM2.5 and Of natural origin (erosion, volcanism …) or anthropogenic (smoke, wear, etc.), these particles remain more or less … “data-image =” https: //cdn.futura-sciences .com / buildsv6 / images / midioriginal / 7 / c / c / 7cc0b6a7e9_50035419_poussiere-pm10-particle-lamio-wikimedia-cc-3.jpg “data-url =” https://www.futura-sciences.com/planete/ definitions / developpement-durable-pm-10-6725 / “data-more =” Read more “>PM10) contained in pollutants from different heat: combustion, an exothermic reaction
The fuel is oxidized and the oxidizer is reduced. This reaction … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/5/f/9/5f91618d35_80925_combustion.jpg “data-url =” https: // www. futura-sciences.com/sciences/definitions/matiere-combustion-3790/ “data-more =” Read more “>combustions causes endothelial disturbances, possible rupture of plaques atheroma plaque forms … “data-image =” https://cdn.futura-sciences.com/buildsv6/images/midioriginal/c/1/ 8 / c18c0eb034_50034477_atherome-prevention-ch.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/medecine-atherome-3035/ “data-more =” Read more “>atheromas and an activation of the sympathetic system thus creating a hypertension. These particles also alter the properties The main anti-inflammatory drugs are aspirin, corticosteroids (or corticosteroids) and non-steroidal anti-inflammatory drugs (NSAIDs).
Their main drawback is their poor digestive tolerance. “Data-url =” https://www.futura-sciences.com/sante/definitions/medecine-anti-inflammatoire-3749/ “data-more =” Read the definition “>anti-inflammatory and antioxidants of HDL (good cholesterol). Not to mention that their mass / size ratio and their reactive surface, allow them to have a high rate of penetration into the functions of the pulmonary alveoli.
The pulmonary alveoli are located deep in the lungs, at the ends of the bronchioles, and are the basic structure where gas exchange takes place between the body and the air … “data-image =” https: // cdn .futura-sciences.com / buildsv6 / images / midioriginal / 3/2/5 / 325e5d9b13_50034672_alveole-virtualmedicalcentre.jpg “data-url =” https://www.futura-sciences.com/sante/definitions/biologie-alveole- pulmonaire-4254 / “data-more =” Read more “>pulmonary alveoli.

The light pollution is also mentioned as an additional factor influencing a disturbance of rhythms Such biological rhythms exist in all living beings, bacteria included, and are manifested by cyclic variations of a large number of physiological parameters … “data-url =” https://www.futura-sciences.com/sante/definitions/biologie-circadien-2148/ “data-more =” Read more “>circadiens and in fact of the inflammatory and oxidative processes already mentioned. The light pollution, defined as outdoor lighting unnecessary for human activities, has greatly increased in urban areas.

Factors favoring cardiovascular disease

All these environmental factors trigger a set of physiopathological signs oriented towards the notion of oxidative stress and inflammation which are factors known to accentuate the cardiovascular risk. These biological mechanisms are also triggered by behaviors at personal risk, it is difficult to separate things in studies of exposomes. Nevertheless, the authors of this meta-analysis propose measures to mitigate noise, atmospheric and light pollution and invite a urban planning intelligent to reduce the burden of stressors leading to cardiovascular health problems and morbidity important.

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