untreated Sleep Apnea Linked to Substantially higher ParkinsonS disease Risk
WASHINGTON – A new study published November 25, 2025, reveals a ample connection between obstructive sleep apnea and an increased risk of developing Parkinson’s disease. Researchers found individuals with untreated sleep apnea may face a dramatically elevated likelihood of being diagnosed with the neurodegenerative disorder, possibly years before typical symptom onset.
The findings, published in JAMA Neurology, underscore the importance of diagnosing and treating sleep apnea, a condition affecting millions worldwide. While Parkinson’s disease impacts an estimated one million Americans,according to the Parkinson’s Foundation,this research suggests a modifiable risk factor could play a critical role in both prevention and early detection. The study’s implications are especially notable given the rising prevalence of both sleep apnea and Parkinson’s disease within aging populations.
The research team, led by Dr. mauricio Manzano at the University of Washington, analyzed data from over 18,000 individuals diagnosed with sleep apnea between 2007 and 2021. Comparing this group to a control cohort without sleep apnea, they discovered those with the sleep disorder had a 53% higher risk of developing Parkinson’s disease. This increased risk persisted even after accounting for othre known Parkinson’s risk factors such as age, sex, race, and cardiovascular health.
Notably, the study indicated the risk was most pronounced within the first five years of a sleep apnea diagnosis. This suggests early intervention and consistent treatment-typically with continuous positive airway pressure (CPAP) therapy-could be crucial in mitigating the potential neurological consequences. Researchers hypothesize that repeated oxygen deprivation during sleep,a hallmark of sleep apnea,may contribute to the neurodegeneration characteristic of Parkinson’s disease.
“We observed a clear temporal relationship,” explained Dr. Manzano.”The closer the diagnosis of sleep apnea was to a subsequent parkinson’s diagnosis, the stronger the association.”
The study’s authors emphasize the need for further research to fully elucidate the underlying mechanisms linking sleep apnea and Parkinson’s disease. However, they recommend that individuals experiencing symptoms of sleep apnea-such as loud snoring, daytime sleepiness, and pauses in breathing during sleep-consult a healthcare professional for evaluation and potential treatment.
