summary of Research Presented at the 13th ASEBIR Embryology Congress by UAB Researchers
Researchers from the Universitat autònoma de Barcelona (UAB) presented significant findings at the 13th ASEBIR Embryology Congress, focusing on the impact of nanoplastics on reproductive health and new insights into the molecular basis of male infertility.
1. Nanoplastics and Reproductive Health:
* Harmful Effects on Sperm: Nanoplastics can adhere to sperm, reducing their motility, membrane integrity, and ability to undergo the acrosomal reaction – all crucial for fertilization.
* Protection of early Embryos: The zona pellucida protects oocytes and preimplantation embryos from nanoplastic damage. However, damage to or loss of the zona pellucida allows nanoplastics to enter cells, reducing embryo viability and implantation potential.
* Call for Further Research: The study emphasizes the need for more research into nanoplastic effects on human reproduction and measures to reduce environmental exposure.
2.New Insights into Male Infertility:
* Sperm Transcriptomics as a Diagnostic Tool: Analysis of sperm mRNA expression profiles can identify biomarkers to diagnose and predict outcomes in male infertility,perhaps leading to more personalized assessments and treatment in assisted reproductive technologies (ART). This research was a collaboration with Dexeus University Hospital, Fertilab and Reproclinic.
* Role of SYCP3 and SIRT7 in Chromosome Pairing: Research using mouse models revealed that homologous chromosome pairing, a critical step in sperm formation, begins before the onset of meiosis. The genes SYCP3 and SIRT7 play a key role in this process, and their absence compromises gamete viability. This discovery redefines understanding of early spermatogenesis.
Funding & Congress Facts:
* Both studies were supported by funding from the Carlos III Health Institute,AGAUR,and the UAB.
* The ASEBIR congress, held annually since 2001, aims to promote research and collaboration in reproductive science.
source: UAB Public Release via Mirage.News (https://www.miragenews.com/uab-joins-13th-asebir-embryology-congress-1569001/)
