Alzheimer’s Reconsidered: New Theory Points to Autoimmune Basis of Disease
TORONTO - A leading researcher is challenging the long-held belief that Alzheimer’s disease originates primarily in the brain,proposing rather that it might potentially be an autoimmune condition – a misdirected immune response attacking the brain. Donald Weaver, Professor of Chemistry and Director of Krembil Research Institute at the University of Toronto, argues this new understanding could revolutionize treatment approaches for the devastating disease.
Alzheimer’s disease currently affects millions worldwide, with a new diagnosis being made every three seconds. The condition often leads to a loss of recognition, even of close family members, with individuals unable to identify their own children or spouses of over 50 years. This escalating public health crisis places a critically importent strain on healthcare systems already burdened by rising costs and demands.
weaver’s research suggests that the brain might potentially be damaged by the immune system as it attempts to fight off an initial infection, possibly triggered by common pathogens. This immune response, while initially intended to protect, could mistakenly target brain tissue, leading to the characteristic hallmarks of Alzheimer’s, such as amyloid plaques and tau tangles.
“We need a better understanding of Alzheimer’s, its causes, and what we can do to treat it and to help the people and families who are living with it,” Weaver stated. The current focus on brain-centric treatments may be overlooking the crucial role of the immune system in the disease’s progression.
This theory,initially published in September 2022 and gaining traction,underscores the urgent need for innovative research and fresh perspectives in tackling Alzheimer’s disease and supporting those impacted by dementia.
