World’s Oldest Person’s Longevity linked to Genetic variants, Possible Lifestyle Factors
New York – Maria Branyas Morera, who recently became the world’s oldest living person at age 117, offers a rare glimpse into the secrets of extreme longevity, according to a new study. Researchers pinpointed several genetic variants potentially contributing to her remarkably healthy lifespan, free from cancer, cardiovascular disease, or dementia. The findings, published in Cell Reports Medicine on September 25, 2024, could reshape understanding of the molecular processes behind aging and offer clues for extending healthy lifespans.
Branyas Morera’s case is remarkable. While longevity is influenced by a complex interplay of genetics and environment, her sustained health into a second century of life presents a unique opportunity for scientific investigation. The study, led by Dr. Manel Esteller, aims to disentangle the genetic and lifestyle factors that allowed her to not onyl live a long life, but a healthy one. Understanding these mechanisms could have profound implications for public health, potentially leading to interventions that delay age-related diseases and improve quality of life for an increasingly aging global population.
Born in San Francisco in 1907,Branyas Morera has lived through momentous historical events,including two world wars and a pandemic. She currently resides in a nursing home in Catalonia, Spain. Researchers analyzed samples from Branyas Morera – including blood, saliva, urine, and stool collected at various times – to identify genetic variations that might explain her exceptional health.
The study revealed several genetic variants potentially involved in protecting against age-related diseases. Researchers noted that the findings suggest advanced age and poor health are not certain companions, and can be studied separately at a molecular level. While acknowledging the limitations of drawing broad conclusions from a single individual, the team emphasized the importance of further research into these genetic factors.
Beyond genetics,researchers also considered lifestyle factors. Branyas Morera is known to enjoy a daily serving of yogurt, a habit some speculate may contribute to her gut health and overall well-being. The study authors caution that aging and extreme longevity are likely highly individualized, and further investigation is needed to determine the relative contributions of genetics and lifestyle.
