Inactivated COVID-19 Vaccine Shows Promise in Dampening Inflammation, Mouse Study Finds
Jakarta, Indonesia - As the world continues to grapple with the long-term effects of the COVID-19 pandemic, research into vaccine efficacy and safety remains paramount. A new study published in Jurnal kedokteran Hewan dan Veteriner (Journal of Medical and Veterinary Science) offers encouraging data regarding the impact of an inactivated SARS-CoV-2 vaccine candidate on inflammatory responses in a mouse model. The research, conducted by Covered Abdul Rantam, suggests the vaccine is safe and effectively modulates key inflammatory markers.
The study focused on K18-hACE2 mice, a genetically engineered strain that expresses the human angiotensin-converting enzyme 2 (hACE2) receptor - the protein that SARS-CoV-2 uses to enter cells. This makes them a valuable model for studying COVID-19 in a laboratory setting. Researchers compared the effects of the inactivated vaccine candidate against a placebo (pseudo vaccine) and a carrier vaccine.
A key objective was to assess the vaccine’s impact on body weight, a common indicator of overall health, and levels of pro-inflammatory cytokines – signaling molecules that play a crucial role in the body’s immune response. These cytokines included interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ).
The findings revealed that administration of the inactivated vaccine candidate did not result in critically important weight changes in the mice compared to the control group.More importantly, the study demonstrated a significant reduction in the levels of all four measured cytokines (IL-4, IL-6, TNF-α, and IFN-γ) in vaccinated mice. This suggests the vaccine effectively dampened the inflammatory response, a hallmark of severe COVID-19.
“These results indicate a favorable safety profile and potential benefits associated with this inactivated SARS-CoV-2 vaccine candidate,” explains the study. “The ability to regulate these key inflammatory markers is crucial in mitigating the severity of COVID-19 and preventing long-term complications.”
While further research is needed, these findings contribute valuable data to the ongoing effort to develop safe and effective COVID-19 vaccines. The study underscores the importance of understanding not only a vaccine’s ability to generate an immune response, but also its impact on the inflammatory cascade that can drive severe disease.
Source: Evaluation and its Impact of SARS-CoV-2 Inactivated Vaccine Candidate in K18-hACE2 mice. jur. Med.Vet.; Vol.8 No.1, 54-62. Available at: https://e-journal.unair.ac.id/JMV
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