Blocking oxygen consumption of brain tumor cells to activate surrounding innate immune cells
Improving the responsiveness of low immunotherapy in brain tumors
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▲ Investigation of the mechanism of anti-brain tumor immune response of gamma delta T cells / Brain tumor cells recognize typical T cells (CD4 T, CD8 T) immune responses that fight by recognizing as antigens to remove tumors. This is because brain tumor cells do not produce as many markers (MHC) that these immune cells can recognize. On the other hand, gamma delta T cells have a receptor (NKG2D) that directly recognizes a ligand (NKG2DL(Rae1)) that occurs a lot on the surface of brain tumor cells exposed to stress even without these antigenic markers, and is attracting attention as a new subject of immune response against tumor . However, due to excessive oxygen consumption of brain tumor cells, the receptor production of gamma delta T cells exposed to hypoxic environment was not smooth, and brain tumor cell cognitive ability decreased. As a result of inhibiting oxygen inflow to brain tumor cells using metformin, gamma delta T cells can utilize the remaining oxygen, and as a result, gamma delta T cells normally make receptors, thereby recognizing brain tumor cells and inducing death. The ability to be able to improve is improved / Picture description and picture provided by Professor Lee Heung-gyu, KAIST © Patent News |
A brain tumor is a type of tumor that occurs in the brain., Known as a tumor with a very poor prognosis. In particular, malignant brain tumors such as glioblastoma have an average survival time. 1~2Belongs to the very short side of the year,, It is known that the effects of existing treatments are very poor, Recurrence is frequent.
These times, Brain tumor cells eat the surrounding oxygen and neutralize immune cells. The secret to avoiding even innate immune cells has been revealed by brain tumor cells that do not produce a marker to be recognized by acquired immune cells..
The Korea Research Foundation KAIST Prof. Heung-Gyu Lee’s research team found gamma delta caused by excessive oxygen consumption in malignant brain tumor cells. T That the process of lowering the immune response of cells 16Sun said.
Note that, Gamma delta(γδ) T Cells are congenital that mainly exist in mucous membranes such as the skin or intestines. T It is known as an important cell in case of early removal of stressed cells or infection with bacteria..
The method of preventing oxygen inflow to brain tumor cells, which proliferate vigorously and rapidly consume surrounding oxygen, is expected to be a clue to complement the low reactivity of immunotherapy drugs..
The research team found that the higher the malignancy of the brain tumor, the higher the gamma delta. T It was found that the influx of cells into the tumor was small and the hypoxic environment was severe.. Whereas gamma delta T The more cells were introduced, the better the patient’s prognosis was..
Acquired, well known as immune cells against tumors T Gamma delta, not cells T This is the reason for paying attention to cell activity..
Thus, gamma delta is solved by reducing the hypoxic environment. T Providing adequate oxygen to cells, We hypothesized that if we help cells survive, the immune response will be normalized..
Real gamma delta T Cells are ligands that occur on the surface of brain tumor cells exposed to stress.(NKG2DL)Receptors that directly recognize(NKG2D)Was attracting attention as a new subject of immune response against tumors, but it was not producing the expected effect..
Compounds to prevent excessive oxygen metabolism of brain tumors in real brain tumor mouse models(Metformin)Gamma delta T Let’s administer it with the cells, Increased penetration of immune cells into tumor tissue and improved survival rate..
Gamma delta TLet’s get rid of the hypoxic environment of cells, The anti-tumor immune response is improved..
Gamma delta T Investigate the mechanism of cellular anti-brain tumor immune response and gamma delta T This study, which suggested ways to increase the immune response of cells, is an international journal in the field of immunology. ‘Nature Immunology(Nature Immunology)’ 2month 11Was published on the date.
On the other hand, Nature Immunology publishes a paper containing this research result,(News & Views) This article was introduced in the corner..
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